Lack of age-dependent cisplatin nephrotoxicity

The American Journal of Medicine
W J HrusheskyB J Kennedy

Abstract

Cisplatin nephrotoxicity was evaluated by serial pretreatment and post-treatment 24-hour creatinine clearance determinations in 43 patients who received 295 monthly infusions of 60 mg/m2 of this drug. An aggressive standard hydration protocol was used without diuretic administration. Fourteen of these patients had a single kidney. Older patients and patients with a single kidney had lower pretreatment creatinine clearances when compared with younger persons with two functioning kidneys. Older and younger patients with two kidneys had an equal, progressive, dose-related deterioration of renal function. Renal function did not decline in persons with a single kidney but did so markedly in those with two kidneys. When administered at 60 mg/m2, cisplatin dose or schedule modification is not indicated on the basis of advancing age or decreased renal function secondary to the surgical loss or total ureteral obstruction of one kidney.

References

Apr 1, 1977·Cancer·J C Gonzales-VitaleS S Sternberg
Nov 1, 1981·Annals of Internal Medicine·J D Blachley, J B Hill

❮ Previous
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Citations

Jan 1, 1986·Cancer Chemotherapy and Pharmacology·M P GorenM E Horowitz
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·M E RobbinsE Whitehouse
Oct 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M SchellM Brunat-Mentigny
Jun 1, 1988·Archives of Gerontology and Geriatrics·L BalducciC L Hardy
May 1, 1996·Cancer Treatment Reviews·V ZagonelA Pinto
Mar 13, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Aapro
Apr 25, 2003·Critical Reviews in Oncology/hematology·Stuart M LichtmanSunitha Vemulapalli
Oct 14, 1998·Japanese Journal of Clinical Oncology·I SekineN Saijo
Jun 1, 1991·British Journal of Urology·A SellaK Fitz
Oct 24, 2000·Drugs & Aging·R J Stephens, D H Johnson
Apr 4, 2002·Drugs & Aging·J Andrew Skirvin, Stuart M Lichtman
Jul 3, 2002·Drugs & Aging·Stuart Hinton, Alan Sandler
Jul 24, 2003·Drugs & Aging·Veena JohnStuart Lichtman
Nov 11, 2003·Clinical Pharmacokinetics·Hans WildiersAllan T van Oosterom
Dec 16, 2005·Clinical Lung Cancer·Jennifer GarstJeffrey Crawford
Sep 16, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B H AliM O Tanira
Feb 1, 1987·Seminars in Oncology Nursing·M Goodman
Apr 14, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sheron LatchaCarlos D Flombaum
Apr 1, 1996·Journal of the American Geriatrics Society·S M LichtmanV Vinciguerra
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stuart M LichtmanUNKNOWN International Society of Geriatric Oncology Chemotherapy Taskforce
Feb 21, 2002·AACN Clinical Issues·Jennifer K Simpson, Margaret Quinn Rosenzweig
Sep 1, 1991·Cancer·C M LindleyS J Tremont
Dec 15, 2005·Cancer·Najat C DawWilliam H Meyer
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W H MeyerB D Fletcher
Nov 23, 2000·Cancer Control : Journal of the Moffitt Cancer Center·S M Lichtman, G Villani
Jun 3, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mingjun ShiMing Chang Hu
Jul 1, 1996·The Annals of Pharmacotherapy·G O UdeaniT E Lad
Dec 1, 1993·The Annals of Pharmacotherapy·A J Anand, B Bashey

❮ Previous
Next ❯

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