PMID: 15333489Aug 31, 2004Paper

Lack of agreement between the revised criteria of impaired fasting glucose and impaired glucose tolerance in children with excess body weight

Diabetes Care
Rita Gómez-DíazNiels H Wacher

Abstract

The aim of this study was to describe the agreement between impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) in children with excess body weight using the original and the revised definitions of IFG. Obese and overweight children aged 4-17 years were included (n = 533). Anthropometric parameters and biochemical tests (fasting and 2-h glucose tests after an oral glucose load [1.75 g/kg]) were performed. Case subjects with a fasting plasma glucose >/=126 mg/dl were excluded. The diagnostic parameters of the original and the revised definitions of IFG for detecting IGT were estimated. The analysis of agreement between these categories was made using the kappa test. The prevalence of IFG increased from 6.2 to 13.3% using the new criteria. The prevalence of IFG became closer to the prevalence of IGT (14.8%). The revised criteria increased the sensitivity from 26.6 to 36.7%. However, the new IFG definition was not useful for identifying IGT cases. Of the 71 case subjects with IFG, only 29 (40.8%) had IGT. In addition, 50 case subjects with IGT (9.4%) and 13 with diabetes (2.4%) had a fasting glycemia <100 mg/dl. A poor agreement was found between the 2003 IFG definition and abnormal 2-h postchallenge plasma glucose...Continue Reading

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Citations

Jun 1, 2005·Archives of Medical Research·Carlos A Aguilar-SalinasJuan A Rull
Oct 26, 2005·Archives of Disease in Childhood·M A SabinJ P H Shield
Feb 29, 2008·BMC Genetics·Qinghua NieXiquan Zhang
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Aug 9, 2007·Journal of the Cardiometabolic Syndrome·Celia Aradillas-GarcíaJuan Francisco Hernández Sierra
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Oct 24, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ludivina Robles-OsorioJuan A Rull
Sep 28, 2005·Diabetes Care·Marc J WeigensbergMichael I Goran

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