Lack of an association between angiotensin receptor blocker based therapy and increased risk of cancer: evidence from large observational studies

PloS One
Yuan YangDayi Hu

Abstract

A previous meta-analysis of randomized controlled studies that were not designed to investigate cancer as a primary outcome suggested that ARB-based therapy is associated with increased risk of cancer; however, results of recent observational studies considering the association have been contradictory. This study sought to evaluate the association between angiotensin receptor blocker (ARB)-based therapy and risk of cancer by conducting a meta-analysis of observational studies. Relevant articles published before February 2014 were identified by searching PubMed and the Cochrane Library. Pooled relative risks (RRs) were determined using a random effects model and were used to assess the strength of association between use of ARB-based therapy and risk of cancer. Six retrospective cohort studies involving a total of 3,827,109 participants and four case-control studies involving a total of 193,029 cases were included. The present study found that ARB-based therapy was not significantly associated with an increased risk of cancer (RR = 0.87, 95%CI: [0.75, 1.01]). However, an analysis including only cohort studies suggested a significantly decreased risk of cancer among individuals with any history of ARB use as compared to those wit...Continue Reading

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Citations

Sep 12, 2015·Journal of Digestive Diseases·Yoshitaka WatanabeKazuhiko Koike
Jul 7, 2020·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Xia ChenKuang-Guan Ya

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