Lack of an association between delayed memory and hippocampal and temporal lobe size in patients with schizophrenia and healthy controls

Biological Psychiatry
I J TorresN C Andreasen

Abstract

The purpose of the present study was to investigate putative neural substrates of long-term (delayed) memory in schizophrenia and young healthy controls. Ten "low" and 10 "high" memory patients were selected from a large sample of DSM-III-R diagnosed schizophrenia spectrum patients, based on composite verbal and nonverbal delayed recall memory scores. Ten "low" and 9 "high" memory individuals were also selected from a larger sample of young healthy controls. Magnetic resonance imaging scans were acquired on a 1.5-T GE Signa scanner using a SPGR sequence (repetition time = 24 msec, echo time = 5 msec). Hippocampal volumes were computed from manual tracings (intraclass correlation = .96), and temporal lobe and whole brain tissue volumes were obtained using a semiautomated technique. In both the patient sample and controls, there was no significant relationship between delayed memory ability and hippocampal, temporal lobe, or whole brain volume. The integration of results from this study, and from studies on normal aging and Alzheimer's disease, supports a model suggesting that hippocampal size may be an indicator of long-term memory ability, but only when hippocampal measures reflect aging and degenerative hippocampal atrophy. If...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L R SquireM E Raichle
Nov 1, 1991·Archives of General Psychiatry·S HeckersH Beckmann
Jan 1, 1991·Schizophrenia Bulletin·F M BenesE D Bird
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
May 1, 1991·Psychiatry Research·S ArndtN C Andreasen
Jul 1, 1991·Archives of General Psychiatry·A J SaykinP Stafiniak
Nov 1, 1990·Archives of General Psychiatry·S HeckersH Beckmann
Mar 22, 1990·The New England Journal of Medicine·R L SuddathD R Weinberger
Jun 1, 1988·Archives of General Psychiatry·J R KelsoeD R Weinberger
Jun 1, 1987·Scientific American·M Mishkin, T Appenzeller
Jan 1, 1986·European Archives of Psychiatry and Neurological Sciences·P Falkai, B Bogerts
Aug 1, 1985·Archives of General Psychiatry·B BogertsR Schönfeldt-Bausch
May 1, 1995·The American Journal of Psychiatry·S E ArnoldJ Q Trojanowski
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·N C AndreasenR D Hichwa
Mar 1, 1995·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·N KapurR S Frackowiak
Dec 14, 1994·JAMA : the Journal of the American Medical Association·N C AndreasenW T Yuh
Apr 15, 1994·Biological Psychiatry·R B ZipurskyA Pfefferbaum
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·E TulvingS Houle
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·E TulvingS Houle
Jan 1, 1994·The American Journal of Psychiatry·J J Blanchard, J M Neale
Jul 1, 1993·The Journal of Nervous and Mental Disease·W W BeattyR D Staton
Jan 1, 1993·The American Journal of Psychiatry·R W BuchananW T Carpenter
Feb 15, 1993·Biological Psychiatry·B BogertsS Masiar
Apr 1, 1993·Psychiatry Research·C ColomboS Scarone
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L SchacterM S Albert
Jan 1, 1995·Journal of the International Neuropsychological Society : JINS·J S PaulsenD V Jeste

❮ Previous
Next ❯

Citations

May 11, 2010·Brain Imaging and Behavior·Li ShenLaura A Flashman
Aug 27, 2004·Schizophrenia Research·Elena AntonovaVeena Kumari
Dec 28, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J GruzelierA Richardson
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Nov 1, 2002·Schizophrenia Research·Lisa J PhillipsPatrick D McGorry
Feb 20, 2003·Schizophrenia Research·Mary P PeguesRaymond F Deicken
Jul 14, 1999·Schizophrenia Research·R F DeickenD Amend
Sep 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D GothelfA Weizman
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Robert J ThomaJose M Cañive
Mar 31, 2005·The American Psychologist·R Walter Heinrichs
Aug 2, 2002·Journal of Abnormal Psychology·Deanna M BarchAbraham Z Snyder
Mar 17, 2007·The Clinical Neuropsychologist·Tara L McHughLi Shen
Nov 4, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanHarald Scherk
Dec 21, 2005·Brain : a Journal of Neurology·H SchmidtR Nau
Aug 3, 2007·International Review of Psychiatry·Benedicto Crespo-FacorroJosé Manuel Rodríguez-Sánchez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.