PMID: 9416720Jan 7, 1998Paper

Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers

Anesthesiology
J LötschG Geisslinger

Abstract

The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine. In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experi...Continue Reading

References

Jun 1, 1975·Anesthesiology·H F DonP Taylor
Aug 1, 1992·British Journal of Clinical Pharmacology·R OsborneM Slevin
Oct 1, 1992·Pain·T CramondJ A Watt
Apr 1, 1991·Journal of Pain and Symptom Management·N A HagenC E Inturrisi
Jan 1, 1991·Therapeutic Drug Monitoring·P A Glare, T D Walsh
Oct 1, 1986·Electroencephalography and Clinical Neurophysiology·J HuttunenR Hari
Jul 11, 1985·The New England Journal of Medicine·K M Foley
Apr 1, 1989·British Journal of Clinical Pharmacology·J HasselströmJ Säwe
Sep 26, 1987·Lancet·G W HanksP Poulain
Jan 1, 1986·Annals of the New York Academy of Sciences·G W Pasternak
Jun 14, 1986·British Medical Journal·R J OsborneM L Slevin
Nov 1, 1988·Pain·Agneta WahlströmAnders Rane
Jul 1, 1983·Pain·Eric H Chudler, Willie K Dong
Apr 1, 1994·British Journal of Clinical Pharmacology·T HummelG Kobal
Apr 1, 1994·European Journal of Pharmacology·N SchmidtG Geisslinger
May 1, 1994·British Journal of Clinical Pharmacology·G KobalT Hummel
Feb 1, 1993·Clinical Neuropharmacology·G W Pasternak
May 1, 1993·British Journal of Anaesthesia·M H HannaS Davies

❮ Previous
Next ❯

Citations

Oct 30, 2008·European Journal of Clinical Pharmacology·Janet K CollerAndrew A Somogyi
May 24, 2005·Journal of Pain and Symptom Management·Jörn Lötsch
Jun 1, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·T HummelG Kobal
Feb 6, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Thomas HummelJörn Lötsch
Apr 1, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·T Hummel
Feb 5, 2003·Journal of Pain and Symptom Management·Gertrud AndersenPer Sjøgren
Apr 23, 2002·British Journal of Clinical Pharmacology·Richard T PensonMaurice L Slevin
Apr 12, 2003·Brain : a Journal of Neurology·Irmgard TegederJörn Lötsch
Jun 5, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Dina LelicAsbjørn Mohr Drewes
May 24, 2006·Anesthesia and Analgesia·Eveline L A van DorpAlbert Dahan
Aug 21, 2001·Clinical Pharmacokinetics·J Lötsch, G Geisslinger
Jun 25, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H DoerflerG Kobal
Oct 5, 2006·Current Opinion in Anaesthesiology·A Dahan, B Kest
Oct 7, 2006·Current Opinion in Anaesthesiology·Jörn Lötsch
May 29, 2004·Anesthesiology·Raymonda RombergAlbert Dahan
Jul 21, 2009·Pharmacology & Therapeutics·Jörn LötschIrmgard Tegeder
Jun 14, 2005·Medicinal Research Reviews·Gavin J Kilpatrick, Terry W Smith
Sep 18, 2007·European Journal of Pain : EJP·Albert DahanAshraf Yassen
Apr 20, 2007·Journal of Clinical Pharmacology·Bertold RennerKay Brune
Apr 19, 2013·British Journal of Clinical Pharmacology·Lasse Paludan MalverAsbjørn Mohr Drewes
Mar 11, 2015·The Pharmacogenomics Journal·M BaberG Koren
May 21, 2015·British Journal of Anaesthesia·A Dahan, J Lötsch
Apr 12, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Eva SverrisdóttirMads Kreilgaard
Nov 28, 2006·Pharmacology, Biochemistry, and Behavior·Gang-Wei ShangJun Chen
Jul 15, 1998·Clinical Pharmacology and Therapeutics·J LötschG Geisslinger
Jan 14, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jamal TemsamaniJean-Michel Scherrmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.