Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.

Brain Research
Christopher M PetersJames C Eisenach

Abstract

The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by 5-HT3 receptor antagonists in rats following spinal nerve ligation (SNL) but not sham operation. Despite these physiologic data, the effects of spinal 5-HT3 receptor blockade on behavioral hypersensitivity and neurochemical alterations in spinal serotonergic system have not been thoroughly investigated following spinal nerve ligation in the rat. To test this, we acutely injected intrathecal ondansetron in rats between 14 and 30 days after SNL and assessed effects on thermal and mechanical hypersensitivity. We also determined the density of serotonergic nerve fibers, serotonin content and the levels of 5-HT3 receptors within the spinal cord at this time point. Intrathecal ondansetron (1, 3, 10, 30, and 100microg) produced no effect on behavioral measures of thermal or mechanical hypersensitivity whereas intrathecal morphine (1microg) and gabapentin (200microg) partially reversed thermal and mechanical hypersensitivity following SNL. In additio...Continue Reading

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Citations

May 25, 2013·Clinical and Experimental Pharmacology & Physiology·Liting Deng, Josée Guindon
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming GuFeng Wei
Nov 8, 2015·The Journal of Pain : Official Journal of the American Pain Society·Vipin AroraChristopher M Peters
Aug 15, 2017·Regional Anesthesia and Pain Medicine·Kevin C GreerMohamed Tiouririne
Nov 24, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hiroyuki NakamoriYasutake Shimizu
May 12, 2012·Anesthesia and Analgesia·Masafumi KimuraShigeru Saito
Sep 30, 2016·Journal of Anesthesia·May-Han LohWill Ne-Hooi Loh
Jan 17, 2020·Frontiers in Neuroscience·Lidia BravoJuan Antonio Micó
Oct 2, 2019·Current Neuropharmacology·Rita Bardoni

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