Lack of androgenicity and estrogenicity of the three monomers used in Eastman's Tritan™ copolyesters

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Thomas G OsimitzColleen Toole

Abstract

Eastman Tritan™ copolyester, a novel plastic from Eastman is manufactured utilizing three monomers, di-methylterephthalate (DMT), 1,4-cyclohexanedimethanol (CHDM), and 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD) in various ratios. As with most any polymer, the monomers along with the high molecular weight oligomers, whose toxicity is most commonly represented by the monomers, make up the predominate amount of free chemicals available for leaching into the environment and/or foods. In light of the high level of public concern about the presence of endocrine (primarily estrogenic) activity ascribed to certain plastics and chemicals in the environment, Tritan's™ monomers were evaluated using QSAR for binding to the androgen receptor and estrogen receptors (alpha and beta) as well as a battery of in vitro and in vivo techniques to determine their potential androgenicity or estrogenicity. The findings were universally negative. When these data are coupled with other in vivo data developed to assess systemic toxicity and developmental and reproductive toxicity, the data clearly indicate that these monomers do not pose an androgenic or estrogenic risk to humans. Additional data presented also support such a conclusion for terephtha...Continue Reading

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Citations

Jun 28, 2013·Integrated Environmental Assessment and Management·Sung Jin ParkRaul P Lejano
Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas G OsimitzColleen Toole
Jul 2, 2015·Environmental Health Perspectives·Nate Seltenrich
Dec 6, 2014·Environmental Health : a Global Access Science Source·George D BittnerGuochun He
Apr 5, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Matthias OnghenaAdrian Covaci
Jul 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·George Bittner, Stuart Yaniger
Nov 20, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Matthias OnghenaAdrian Covaci
Oct 19, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Coraline SimonMarc Elskens
Apr 18, 2014·Nature·Josie Glausiusz
Nov 18, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Fabrian BrenzThomas J Simat

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