Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation

Fundamental & Clinical Pharmacology
L Bach-RojeckyZdravko Lacković

Abstract

Botulinum toxin type A (BTX-A) has a long-lasting antinociceptive activity and less clear effect on inflammation. It was proposed that these two effects share the same mechanism--the inhibition of neurotransmitter exocytosis from peripheral nerve endings. However, till now possible anti-inflammatory action of BTX-A did not evoke much attention. In the present paper, we investigate possible anti-inflammatory action of the toxin in carrageenan and capsaicin models of inflammation in rats. BTX-A (5 and 10 U/kg) was injected into the plantar surface of the rat right hind-paw pad 5 days before the injection of the carrageenan (1%) or capsaicin (0.1%) at the same site. Carrageenan-induced paw oedema and capsaicin-induced protein extravasation were measured. Control, inflamed and BTX-A pretreated inflamed paws were photographed and histopathological analysis (haematoxylin & eosin) was performed. Pretreatment with BTX-A had no effect on the size of carrageenan-induced paw oedema, measured as paw volume and weight or capsaicin-induced plasma extravasations, measured by Evans blue as a marker of protein leakage. Neither macroscopic nor microscopic analysis showed a significant difference between BTX-A pretreated and control inflamed tiss...Continue Reading

References

Nov 1, 1989·Annals of the Rheumatic Diseases·F Y Lam, W R Ferrell
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·K UdakaH Z Movat
Aug 28, 1998·The Prostate·R DoggweilerR A Schmidt
Feb 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·M J WelchK A Foster
Feb 25, 2003·Urological Research·Selahittin CayanErcüment Ulusoy
Jul 23, 2003·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bahman JabbariMarc P Difazio
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Mar 3, 2004·Journal of Neurology·Hartmut Göbel
Jun 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
Feb 22, 2005·The Clinical Journal of Pain·Nasser AllamCarlos Tomaz
Apr 15, 2005·Arquivos de neuro-psiquiatria·Dirk DresslerEgberto Reis Barbosa
May 24, 2005·Pflügers Archiv : European journal of physiology·Rosa Planells-CasesAntonio Ferrer-Montiel
Mar 10, 2006·Brain Research·Siro LuvisettoFlaminia Pavone
Jun 21, 2006·Neurotoxicity Research·M L MahowaldD Dykstra
Jul 28, 2006·Parkinsonism & Related Disorders·Daniel D Truong, Wolfgang H Jost
May 8, 2007·Journal of the Neurological Sciences·Wilhelm J Schulte-MattlerKai Wohlfahrt

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Citations

Jun 10, 2010·Aesthetic Plastic Surgery·Daniel Wasserman, Gary Monheit
Feb 3, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hee-Ryung ChoWoo-Young Sim
Nov 10, 2011·Toxins·Flaminia Pavone, Siro Luvisetto
Jun 11, 2014·Progress in Neurobiology·Ivica Matak, Zdravko Lacković
Aug 20, 2015·Toxins·Hyun-Mi Oh, Myung Eun Chung
Sep 8, 2009·Pharmacology, Biochemistry, and Behavior·Lidija Bach-Rojecky, Zdravko Lacković
May 14, 2014·British Journal of Pharmacology·Roshni Ramachandran, Tony L Yaksh
Jan 14, 2016·Pain·Antonina S MangioneStephen P Hunt
Dec 29, 2012·Toxicon : Official Journal of the International Society on Toxinology·Min-Chul ShinNorio Akaike
Dec 23, 2014·Toxicon : Official Journal of the International Society on Toxinology·Siro LuvisettoCarlo Cianchetti
Aug 25, 2017·Toxins·JungHyun Park, Hue Jung Park
Aug 11, 2016·Journal of Neural Transmission·V Drinovac VlahZ Lacković
Aug 8, 2019·Toxins·Ivica MatakZsuzsanna Helyes
Aug 28, 2020·Frontiers in Neurology·Gabriella EgeoPiero Barbanti
Nov 13, 2020·Frontiers in Pharmacology·Luka LovrenčićZdravko Lacković
Jul 10, 2020·Sexual Medicine Reviews·Amit G ReddyWayne J G Hellstrom
Apr 1, 2021·JAAD Case Reports·Haya S Raef, Sarina B Elmariah
Mar 17, 2020·Toxicon : Official Journal of the International Society on Toxinology·Zdravko Lacković

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