Lack of association between acellular pertussis vaccine and seizures in early childhood

Pediatrics
Wan-Ting HuangVaccine Safety Datalink Team

Abstract

Receipt of diphtheria-tetanus-whole-cell pertussis vaccine (diphtheria-tetanus toxoids-pertussis [DTP]) is associated with seizures. Limited population-based studies have been conducted on the risk for seizures after receipt of diphtheria-tetanus-acellular pertussis vaccine (diphtheria-tetanus-acellular pertussis [DTaP]). We conducted a retrospective study from 1997-2006 by using risk-interval cohort and self-controlled case series (SCCS) analyses on automated data at 7 managed care organizations that participate in the Vaccine Safety Datalink (VSD). Eligible children included the 1997-2006 VSD cohort of patients who were aged 6 weeks to 23 months and had not received DTP during the study period. A seizure event (febrile or afebrile) was defined by International Classification of Diseases, Ninth Revision, Clinical Modification diagnoses assigned to an inpatient or emergency department setting. The exposed period was composed of a predefined 4 person-days after each DTaP dose. All of the remaining observation periods outside the exposed periods were categorized as unexposed. The risk-interval cohort method compared the incidence of seizures between the exposed and unexposed cohorts. In the SCCS method, the comparison was perform...Continue Reading

Citations

May 13, 2011·Epilepsia·Fernando Cendes, Raman Sankar
Jun 23, 2011·Epilepsia·Sarah von SpiczakBrigitte Keller-Stanislawski
Mar 5, 2011·Indian Journal of Pediatrics·Sunil Karande
Aug 30, 2013·Expert Review of Vaccines·Nicola Principi, Susanna Esposito
Feb 7, 2016·Vaccine·Juan David SarmientoClaudia M Trujillo-Vargas
Sep 17, 2013·Statistics in Medicine·Yonas Ghebremichael-WeldeselassieC Paddy Farrington
Oct 23, 2013·Epilepsia·Dario PrunaAlberto Verrotti
Oct 5, 2018·Biometrical Journal. Biometrische Zeitschrift·Heather J WhitakerC Paddy Farrington
Nov 26, 2019·Nursing·Paula Barbel
Sep 27, 2019·Frontiers in Cellular and Infection Microbiology·Keith Rubin, Steven Glazer
Apr 28, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Jennifer L LiangThomas A Clark
Apr 18, 2020·The Pediatric Infectious Disease Journal·Karina A TopSalaheddin M Mahmud
Aug 15, 2021·Seizure : the Journal of the British Epilepsy Association·Fathi MassoudMaher Arabi

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