Lack of association between amplification of her-2 and response to preoperative taxanes in patients with breast carcinoma

Cancer
Ana M Gonzalez-AnguloFrancisco J Esteva

Abstract

The objective of the current study was to determine whether her-2 amplification was associated with a pathologic response to preoperative chemotherapy with taxanes in patients with early-stage breast carcinoma. The authors evaluated 71 patients treated for AJCC Stage II and III breast carcinoma with preoperative taxanes whose tissue specimens were still available. Fifty-seven patients (80%) had received paclitaxel and 14 (20%) had received docetaxel (4 cycles of either drug). Amplification of the her-2 gene was determined using fluorescence in situ hybridization. The median patient age was 49 years (range, 21-70 years). Forty-eight patients (68%) had Stage II breast carcinoma and 23 (32%) had Stage III disease. her-2 gene amplification was detected in 19 tumor specimens (28%). Hormone receptors (estrogen and/or progesterone) were detected in 11 her-2-positive tumor specimens (58%) and in 31 her-2-negative tumor specimens (85%). Eight pathologic complete responses (pCR; breast and axillary lymph nodes) occurred, 3 (16%) in patients with her-2-positive tumor specimens and five (10%) in patients with her-2-negative tumor specimens (P = 0.68). Twelve patients achieved pCR in the breast, 5 (26%) in patients with her-2-positive tumor...Continue Reading

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Citations

May 1, 2007·Breast Cancer Research and Treatment·Fabrice AndreLajos Pusztai
Feb 21, 2013·Breast Cancer Research and Treatment·Miguel MartínPhilip S Bernard
Jan 25, 2006·Saudi Medical Journal·Layla J Al-Mansouri, Majed S Alokail
Oct 12, 2007·The New England Journal of Medicine·Daniel F HayesUNKNOWN Cancer and Leukemia Group B (CALGB) Investigators
Apr 6, 2011·Breast Cancer Research and Treatment·M MartinC M Perou
Dec 7, 2014·Cancer Chemotherapy and Pharmacology·Xi GuWen-Hai Zhang
Apr 25, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Miguel Martín
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun LuAnna G Sorace

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