Lack of association between angiotensin I-converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain

International Journal of Dermatology
Pablo Coto-SeguraJorge Santos-Juanes

Abstract

Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conducted among 268 unrelated patients with psoriasis and 272 controls. The distribution of DD, ID, and II genotypes did not significantly differ between psoriatic patients and controls (DD: 39.6% vs. 34.2%; ID: 46.3% vs. 53.3%; II: 14.1% vs. 12.5%). In conclusion, the ACE polymorphism is not likely to be associated with either psoriasis or psoriatic arthritis in this study.

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Citations

Jul 7, 2014·Cell Biochemistry and Biophysics·Tianbao XiaShichao Lv
Apr 30, 2013·Clinical and Experimental Dermatology·T LiuL Lu
May 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·S ArmestoJ Santos-Juanes
Feb 19, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Carmen Fiuza-LucesAlejandro Lucia
Apr 17, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gwan Gyu SongYoung Ho Lee
Jul 13, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·KeDa YangDeYun Feng
Feb 16, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gwan Gyu SongYoung Ho Lee

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