Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission.

Therapeutic Advances in Musculoskeletal Disease
Kenneth F BakerJohn D Isaacs

Abstract

The objective of this study was to assess the prevalence of ultrasound (US) abnormalities and association with clinical parameters in rheumatoid arthritis (RA) clinical remission. Patients with established RA in clinical remission (DAS28-CRP < 2.4) taking conventional synthetic disease-modifying anti-rheumatic drugs were recruited as part of the Biomarkers of Remission in Rheumatoid Arthritis (BioRRA) Study. In addition, patients from the Newcastle Early Arthritis Clinic (NEAC) with early active RA (DAS28-CRP > 2.4) or seronegative non-inflammatory arthralgia (NIA) were studied as positive and negative controls, respectively. The association between individual dependent variables (synovial power Doppler and greyscale, tenosynovial greyscale, and erosions) and clinical parameters was assessed by multivariate ordinal logistic regression, with adjustment for multiple testing. A total of 294 patients were included: 66 RA in remission, 146 active RA, and 82 NIA. Within the active RA group, significant associations were observed between swollen joint count and higher total synovial greyscale score (OR 1.17 95% CI 1.08-1.26, p < 0.001) and higher total synovial power Doppler score (OR 1.20, 95% CI 1.12-1.30, p < 0.001). No significant...Continue Reading

References

Jul 2, 2003·Health and Quality of Life Outcomes·Bonnie Bruce, James F Fries
Nov 29, 2015·Annals of the Rheumatic Diseases·Ilaria PadovanoMaria Antonietta D'Agostino
Feb 6, 2019·JAMA : the Journal of the American Medical Association·Daniel Aletaha, Josef S Smolen
Jul 10, 2019·Journal of Autoimmunity·Kenneth F BakerJohn D Isaacs

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Citations

Jun 25, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Luisa BritesJosé António Pereira da da Silva

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