Lack of association between epicardial fat volume and extent of coronary artery calcification, severity of coronary artery disease, or presence of myocardial perfusion abnormalities in a diverse, symptomatic patient population: results from the CORE320 multicenter study

Circulation. Cardiovascular Imaging
Yutaka TanamiArmin Arbab-Zadeh

Abstract

Epicardial fat may play a role in the pathogenesis of coronary artery disease (CAD). We explored the relationship of epicardial fat volume (EFV) with the presence and severity of CAD or myocardial perfusion abnormalities in a diverse, symptomatic patient population. Patients (n=380) with known or suspected CAD who underwent 320-detector row computed tomographic angiography, nuclear stress perfusion imaging, and clinically driven invasive coronary angiography for the CORE320 international study were included. EFV was defined as adipose tissue within the pericardial borders as assessed by computed tomography using semiautomatic software. We used linear and logistic regression models to assess the relationship of EFV with coronary calcium score, stenosis severity by quantitative coronary angiography, and myocardial perfusion abnormalities by single photon emission computed tomography (SPECT). Median EFV among patients (median age, 62.6 years) was 102 cm(3) (interquartile range: 53). A coronary calcium score of ≥1 was present in 83% of patients. Fifty-nine percent of patients had ≥1 coronary artery stenosis of ≥50% by quantitative coronary angiography, and 49% had abnormal myocardial perfusion results by SPECT. There were no signif...Continue Reading

References

Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Karen S MoultonJudah Folkman
Aug 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Fumio InoueTakahisa Uchiyama
Jun 2, 2007·American Heart Journal·Harold S Sacks, John N Fain
Feb 2, 2008·Obesity·Joan F CarrollRoberto Cardarelli
Jun 7, 2008·Obesity·Jingzhong DingUNKNOWN Multi-Ethnic Study of Atherosclerosis
Sep 9, 2008·The American Journal of Cardiology·Sanjay SarinJamshid Shirani
Nov 29, 2008·The New England Journal of Medicine·Julie M MillerJoão A C Lima
Dec 10, 2008·The American Journal of Cardiology·Roxana DjaberiJeroen J Bax
Aug 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji UenoSatoshi Ogawa
May 5, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthew JanikPaolo Raggi
Nov 13, 2010·JACC. Cardiovascular Imaging·Balaji TamarappooDaniel S Berman
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Feb 1, 1996·Trends in Cardiovascular Medicine·J K Williams, D D Heistad
Sep 8, 2011·Clinical and Experimental Pharmacology & Physiology·Harold S Sacks, John N Fain
Dec 14, 2011·Cell Biology International·George N ChaldakovLuigi Aloe
Mar 7, 2012·Circulation·Armin Arbab-ZadehValentin Fuster
Aug 14, 2012·Circulation. Cardiovascular Imaging·Rodrigo J CerciJoao A C Lima
Mar 5, 2013·Journal of Cardiovascular Computed Tomography·Mohamed Marwan, Stephan Achenbach
Jan 21, 2014·Progress in Cardiovascular Diseases·Alban De SchutterRichard V Milani
Mar 7, 2014·Journal of the American Heart Association·Timothy P Fitzgibbons, Michael P Czech

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Citations

Jan 29, 2016·Journal of Cardiovascular Computed Tomography·Michaela M HellDamini Dey
Jul 15, 2015·International Journal of Cardiology·Gianfranco ApriglianoNuccia Morici
Nov 21, 2015·The International Journal of Cardiovascular Imaging·Daniela Bertol GraeffBruce Bartholow Duncan
May 31, 2015·Journal of Cardiovascular Computed Tomography·Sasan Partovi, Armin Arbab-Zadeh
Jun 14, 2016·The International Journal of Cardiovascular Imaging·Bai-Chin LeeMing-Fong Chen
Jul 5, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Linda B PauliksLilliam M Valdes-Cruz
Sep 15, 2016·European Heart Journal Cardiovascular Imaging·Filippo CademartiriErica Maffei
Jan 25, 2017·European Journal of Preventive Cardiology·Bénédicte Gaborit, Anne Dutour
Aug 3, 2018·International Heart Journal·Atsuko Nakayama
Aug 26, 2017·Journal of the American Heart Association·Nitesh NerlekarDennis T L Wong
Mar 11, 2015·Circulation. Cardiovascular Imaging·Doan T Ngo, Noyan Gokce
Jun 2, 2018·Heart·Jennifer MancioCharalambos Antoniades
Mar 25, 2019·Cardiovascular Research·Rosalinda MadonnaRaffaele De Caterina
Apr 3, 2019·Menopause : the Journal of the North American Menopause Society·Virginia M MillerS Mitchell Harman
Aug 16, 2017·The International Journal of Cardiovascular Imaging·Kohichiro IwasakiToshihiko Nagao
Apr 7, 2019·Current Hypertension Reports·Thierry H Le JemtelSuzanne Oparil
Aug 28, 2019·Menopause : the Journal of the North American Menopause Society·Virginia M MillerS Mitchell Harman
Feb 21, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wenji YuYuetao Wang
Apr 13, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Emir M MuzurovićDimitri P Mikhailidis

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