Lack of association between five serotonin metabolism-related genes and medication overuse headache.

The Journal of Headache and Pain
S CevoliP Cortelli

Abstract

Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5HTT), serotonin receptor 1A(5-HT1A), serotonin receptor 1B (5-HT1B), serotonin receptor 2A (5-HT2A) and serotonin receptor 6 (5HT6)genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated didnot differ among the three groups. In conclusion, our studydoes not provide evidence that the 5HTT, 5-HT1A, 5HT1B,5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.

References

Dec 15, 1994·Biochemical and Biophysical Research Communications·M M NöthenP Propping
Dec 31, 1997·Italian Journal of Neurological Sciences·L MonariP Montagna
May 28, 1998·Cephalalgia : an International Journal of Headache·A D OgilvieJ Olesen
Jun 22, 1999·Cephalalgia : an International Journal of Headache·M B RussellJ Olesen
Jun 20, 2001·Journal of the Neurological Sciences·M YilmazY A Bayazit
Aug 8, 2001·Journal of the Neurological Sciences·M E ErdalY A Bayazit
Mar 8, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M MochiP Montagna
Jul 21, 2004·Lancet Neurology·Hans-Christoph Diener, Volker Limmroth
Feb 1, 2005·Trends in Pharmacological Sciences·Paolo Calabresi, Letizia Maria Cupini
Jul 5, 2005·Nature Reviews. Genetics·David GoldmanFrancesca Ducci
May 12, 2006·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification CommitteeT J Steiner
Aug 26, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S CevoliP Montagna
Mar 18, 2008·The Journal of Headache and Pain·Pasquale Montagna

❮ Previous
Next ❯

Citations

May 19, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S TerrazzinoA A Genazzani
Feb 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·T OnayaY Kiuchi
Dec 15, 2010·Expert Opinion on Drug Metabolism & Toxicology·Giovanna GentilePaolo Martelletti
Mar 20, 2010·Lancet Neurology·Stefan Evers, Martin Marziniak
Feb 22, 2011·The Journal of Headache and Pain·Maurizio ZappaterraLuigi Alberto Pini
Sep 4, 2012·The Journal of Headache and Pain·Cherubino Di LorenzoFilippo M Santorelli
Sep 3, 2010·Headache·Salvatore TerrazzinoArmando A Genazzani
Jan 29, 2017·Expert Opinion on Pharmacotherapy·Amanda E Macone, Michael D Perloff
Sep 6, 2017·Cephalalgia : an International Journal of Headache·Sarah CargninSalvatore Terrazzino

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Arlequin

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.