Lack of Association between Genetic Risk Loci for Restless Legs Syndrome and Multimorbidity

Sleep
András SzentkirályiKlaus Berger

Abstract

Multimorbidity is a risk factor for incident restless legs syndrome (RLS). In this relationship, the potential role of known genetic risk loci for RLS has not been studied. Our aim was to evaluate whether carriers of specific RLS risk alleles have higher comorbidity burden than noncarriers. The Dortmund Health Study (DHS) and the Study of Health in Pomerania (SHIP) are two independent cohort studies in Germany based on age-stratified, random samples drawn from the respective population registers. DHS included 1,312 subjects and SHIP included 4,308 subjects. RLS status was assessed according to the RLS standard minimal criteria. A comorbidity index was calculated by summing the scores of the following conditions: diabetes, hypertension, myocardial infarction, obesity, stroke, cancer, renal disease, anemia, depression, thyroid disease, and migraine. Thirteen single nucleotide polymorphisms (SNP) previously associated with elevated risk of RLS were genotyped. Analyses were carried out on the pooled sample of the two studies. The mean age was 50.4 ± 15.9 y, and the proportion of women was 51.4%. The mean number of comorbid conditions was 1.5 ± 1.3. In multivariable regression, the mean number of comorbidities was not significantly ...Continue Reading

References

Jul 20, 2002·Journal of Psychosomatic Research·Maurice M Ohayon, Thomas Roth
Jan 28, 2004·Archives of Internal Medicine·Klaus BergerChristof Kessler
Oct 27, 2005·Diabetes Care·Lívia A LopesVeralice M S de Bruin
Dec 20, 2005·Journal of Epidemiology and Community Health·Peter ElwoodJohn Gallacher
Jun 10, 2006·Sleep Medicine Reviews·Diego Garcia-BorregueroKlaus Berger
Jul 20, 2007·The New England Journal of Medicine·Hreinn StefanssonKari Stefansson
Feb 29, 2008·The Journal of Neuropsychiatry and Clinical Neurosciences·Hochang B LeeConstantine G Lyketsos
Jul 29, 2008·Nature Genetics·Barbara SchormairJuliane Winkelmann
Jan 7, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Regina M Taylor-GjevreBindu Nair
Mar 13, 2009·Journal of Medical Genetics·D KemlinkJ Winkelmann
Apr 8, 2009·Neurology·Xiang GaoAlberto Ascherio
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 20, 2010·International Journal of Epidemiology·Henry VölzkeWolfgang Hoffmann
Mar 3, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Luca OstacoliAlfredo Berruti
May 17, 2011·Nature Genetics·Karsten SuhreMatthias Nauck
Oct 12, 2011·Hypertension·Salma Batool-AnwarXiang Gao
Nov 9, 2011·Sleep Medicine·Andras SzentkiralyiKlaus Berger
Nov 26, 2011·Cephalalgia : an International Journal of Headache·Laura KhilKlaus Berger
Mar 8, 2012·Cephalalgia : an International Journal of Headache·Markus SchürksTobias Kurth
Jul 19, 2012·American Journal of Epidemiology·Yanping LiXiang Gao
Jan 18, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kevin P JensenJoel Gelernter
May 9, 2014·Neurology·András SzentkirályiKlaus Berger

❮ Previous
Next ❯

Citations

Jul 29, 2019·Current Neurology and Neuroscience Reports·Semiha Kurt
Sep 25, 2018·Lancet Neurology·Claudia TrenkwalderJuliane Winkelmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.