PMID: 11916624Mar 28, 2002Paper

Lack of association between peroxisome proliferator-activated receptor-gamma-2 gene variants and the occurrence of coronary heart disease in patients with diabetes mellitus

European Journal of Endocrinology
M BlüherR Paschke

Abstract

Recent evidence indicates that peroxisome proliferator-activated receptor-gamma (PPARgamma) is expressed at high levels in foam cells of atherosclerotic lesions, that PPARgamma agonists may directly modulate vessel wall function and that mutations in the PPARgamma-2 gene are associated with a reduced risk of coronary artery disease. We investigated whether known variants in the PPARgamma-2 gene are associated with the occurrence of coronary heart disease (CHD) in 365 patients with type 2 diabetes, prospectively characterised for the presence or absence of CHD. The Pro115Gln, Pro12Ala, Pro467Leu, Val290Met mutations and two polymorphisms C478T and C161T of the PPARgamma-2 gene were examined using PCR, denaturing gradient gel electrophoresis and direct sequencing. The distribution of the Pro12Ala, Ala12Ala, C161T and T161T variants was not significantly different between patients with and without CHD, independent of the gender. The Pro12Ala (P=0.011) and the Ala12Ala (P=0.006) variant were associated with a higher body mass index (BMI) compared with the Pro12Pro genotype. A multiple logistic regression analysis introducing the typical risk factors for CHD (age, sex, hypertension, smoking, BMI >26 kg/m2, elevated low density lipop...Continue Reading

Citations

Dec 18, 2009·PPAR Research·Jean DallongevilleAline Meirhaeghe
May 21, 2014·Journal of Molecular Neuroscience : MN·Khouloud ChehaibiMohamed Naceur Slimane
Feb 7, 2008·International Journal of Cardiology·Konstantinos TziomalosAlexander M Seifalian
Feb 15, 2018·Biomarkers in Medicine·Thelma Beatriz González-CastroMiguel Ángel Ramos-Méndez
Oct 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex S F DoneyColin N A Palmer
Jul 31, 2004·Stroke; a Journal of Cerebral Circulation·Khalid Z Al-ShaliRobert A Hegele
May 28, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Tobias PischonEric B Rimm
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Eun Jung RheeJung Roe Park

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