Lack of association between PSA-NCAM expression and migration in the rostral migratory stream of a Huntington's disease transgenic mouse model

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Louise MoraesRosalia Mendez-Otero

Abstract

Huntington's disease is a neurodegenerative autosomal disorder characterized by selective loss of striatal and cortical neurons. The mammalian brain subventricular zone contains a population of neural precursors involved in postnatal neurogenesis. These newly generated cells migrate from the subventricular zone along the rostral migratory stream and differentiate into mature olfactory bulb neurons throughout adulthood. The establishment of this pathway depends upon a variety of molecules, including polysialylated neural cell adhesion molecule (PSA-NCAM). We used a murine model of Huntington's disease, the R6/2 transgenic mouse, and in vivo bromodeoxyuridine administration to label cells undergoing proliferation and to follow their migration along the rostral migratory stream. Bromodeoxyuridine labeling did not show any significant increase in proliferation of progenitor cells in symptomatic R6/2 mice, but migration of neuroblasts along the rostral migratory stream was significantly diminished. The decrease in neuroblast migration was not due to an alteration in the expression of PSA-NCAM along the rostral migratory stream since immunohistochemical analysis showed no significant differences between R6/2 and wild type mice. In ad...Continue Reading

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Citations

Sep 15, 2010·BMC Neuroscience·Zacharias KohlJürgen Winkler
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christopher W NgErnest Fraenkel
Sep 20, 2011·Biochimica Et Biophysica Acta·Teresa Janas, Tadeusz Janas

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