Lack of Association between STAT4 Single Nucleotide Polymorphisms and Iranian Juvenile Rheumatoid Arthritis Patients

Fetal and Pediatric Pathology
Saeed AslaniNima Rezaei

Abstract

Juvenile rheumatoid arthritis (JRA) is a common chronic systemic autoimmune disease in children. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene are suspected to have association with the risk of autoimmune diseases. Previous investigations have indicated that the STAT4 rs7574865 T allele was significantly associated with rheumatoid arthritis. In this study, we aimed to evaluate the association of STAT4 SNPs with JRA in Iranian population. T allele of STAT4 rs7574865 SNP was less frequent in patients than in controls, and the difference was not significant (p = 0.19, OR = 0.72, 95% CI: 0.44 -1.17). In addition, G allele of this SNP was frequent but not significant in JRA patients (p = 0.19, OR = 1.38, 95% CI: 0.85-2.25). Neither alleles nor genotypes of rs7601754 SNP of STAT4 gene demonstrated associations with JRA. We recognize that gene variants of STAT4 did not affect JRA susceptibility in Iranian population.

References

Nov 11, 1999·Arthritis and Rheumatism·D N Glass, E H Giannini
Nov 18, 2000·Arthritis and Rheumatism·S PrahaladE H Giannini
Jun 10, 2004·Arthritis and Rheumatism·Marta B MoroldoEdward H Giannini
Nov 18, 2004·Immunological Reviews·Wendy T WatfordJohn J O'Shea
May 13, 2005·Immunologic Research·Mark H Kaplan
May 4, 2006·The Journal of Clinical Investigation·Yoichiro Iwakura, Harumichi Ishigame
Mar 6, 2007·Lancet·Angelo Ravelli, Alberto Martini
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anubhav N MathurMark H Kaplan
Jul 23, 2008·Pediatric Rheumatology Online Journal·Sampath Prahalad, David N Glass
Jun 9, 2012·Annals of the Rheumatic Diseases·Alberto Martini
Jun 21, 2012·Molecular Biology Reports·Ya-Ling LiangXiao-Dong Xie
Mar 29, 2014·International Journal of Rheumatic Diseases·Surjit SinghDebashish Danda
Nov 17, 2014·Journal of Assisted Reproduction and Genetics·Mohammad Reza ZamaniNima Rezaei
May 29, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mohammad Reza ZamaniNima Rezaei

❮ Previous
Next ❯

Citations

Jun 25, 2019·Fetal and Pediatric Pathology·Tayyeb BahramiNima Rezaei
Feb 1, 2021·Auto- Immunity Highlights·Meisam GachpazanMeysam Moghbeli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.