Lack of association between the -2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

Tissue Antigens
P G McGlincheyP P McKeown

Abstract

Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibrium test and the pedigree disequilibrium test, no association between the MCP-1 -2518G/A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with IHD.

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Citations

Oct 22, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Iman R El MahgoubDalia G Beda
Jul 25, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Sirri F CamAfig Berdeli
Apr 1, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiaolin ZhangChenghui Yan
Nov 11, 2008·Archives of Medical Research·Gracia Viviana González-EnríquezCaridad Aurea Leal-Cortés
Jan 31, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Riadh JemaaNaziha Kaabachi

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