Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Imen ArfaSonia Abdelhak

Abstract

The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. A case-control study was conducted among 141 unrelated type 2 diabetic patients with (90 patients) or without nephropathy (51 patients) and 103 non-diabetic controls with normal fasting blood glucose. Genotyping was performed using a nested polymerase chain reaction amplification in order to identify correctly heterozygous individuals. The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabetic patients with or without nephropathy (DD: 44%; ID: 46%; II: 10% vs. DD: 41%; ID: 47 %; II: 12%, respectively). There was also no significant statistical difference between the genotype distribution and allele frequencies of the (I/D) polymorphism in all type 2 diabetic subjects compared to non-diabetic controls with normal fasting blood glucose (DD: 43%; ID: 46%; II: 11% vs. DD: 37%; ID: 48%; II: 15%, respectively). In the present preliminary study, the (I/D) polymorphism within the ACE gene is likely not associated with diabetic nephropathy nor with type 2 diabetes in the Tunisian s...Continue Reading

References

Oct 1, 1987·European Journal of Clinical Investigation·K W JauchG Dietze
Feb 1, 1981·Diabetologia·A H BarnettD A Pyke
Mar 1, 1981·Kidney International·T H HostetterB M Brenner
May 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanB J Spray
Jul 1, 1995·Diabetes·P RossingH H Parving
Mar 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S SchmidtE Ritz
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M C HsiehJ H Tsai
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·G J Roth
Nov 5, 2002·Diabetes Research and Clinical Practice·S N T De SilvaD J S Fernando
Jul 23, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·S HadjadjUNKNOWN DIABHYCAR Study Group
Dec 23, 2003·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Errol D CrookBonnie Oliver
Jan 11, 2005·Molecular Genetics and Metabolism·Jeffrey W StephensSteve E Humphries
Apr 20, 2006·Diabetes Research and Clinical Practice·Puneet Pal SinghSarabjit Mastana
Nov 10, 2006·Annals of Human Biology·Maha RebaïAhmed Rebaï

❮ Previous
Next ❯

Citations

Oct 1, 2012·Journal of Nephropathology·Zohreh Rahimi
Feb 3, 2016·Diabetes Research and Clinical Practice·Yandiswa Y YakoAndre P Kengne
Jun 14, 2016·International Journal of Chronic Diseases·Koubaa AfifaSoltani Mohamed
Mar 17, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thouraya BaroudiAmel Benammar-Elgaaied
Oct 23, 2019·International Journal of Environmental Research and Public Health·Yuan-Jung HsuHsiao-Ling Huang
Sep 11, 2010·Molecular and Cellular Biochemistry·Vahid FelehgariAsad Vaisi-Raygani
Sep 18, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yuying WangChenguang Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.