PMID: 12759172May 22, 2003Paper

Lack of association between the interleukin-1alpha gene C(-889)T polymorphism and Alzheimer's disease in a Chinese population

Neuroscience Letters
Shih-Jen TsaiChen-Jee Hong

Abstract

Interleukin 1A (IL-1A), a potent proinflammatory cytokine, has been implicated in the pathogenesis of Alzheimer's disease (AD). Several recent studies have shown that a polymorphism in the IL-1A locus -889 was associated with AD risk and onset age, however, other studies were not able to replicate these findings. In this investigation, the IL-1A C(-889)T polymorphism has been analyzed for a Chinese population of 234 AD patients and 170 controls. There were no significance differences in IL-1A genotype or allele frequencies comparing the AD cases and controls, even after stratification for age of onset and adjustment for apolipoprotein E genotype. The results reveal that it is not likely that the IL-1A C(-889)T polymorphism is involved in AD pathogenesis in the Chinese population. Further studies of the associations between other IL-1A genetic polymorphisms and AD are needed to fully elaborate the involvement of this gene in AD.

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Mar 15, 2000·Annals of Neurology·J A NicollW S Griffin
Mar 26, 2002·Neuroscience Letters·Liana FidaniJohn Hardy
Jul 12, 2002·Annals of Neurology·Ross HedleyRalph N Martins

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Citations

Aug 19, 2008·Cellular and Molecular Neurobiology·Ji-Liang HuYan-Jun Zeng
Mar 17, 2004·Current Opinion in Lipidology·Nicole Helbecque, Philippe Amouyel
Oct 6, 2012·American Journal of Alzheimer's Disease and Other Dementias·Saliha Handan YildizEvrim Suna Arikan Terzi
Jul 12, 2007·Dementia and Geriatric Cognitive Disorders·Hsiu-Kuan WangChiung-Mei Chen
Dec 10, 2003·International Journal of Geriatric Psychiatry

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