Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patients with rheumatoid arthritis.

DNA and Cell Biology
Mercedes García-BermúdezMiguel A Gonzalez-Gay

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Toll-like receptor-4 (TLR4) activates the innate immune response via NF-kB pathway and mitogen-activated protein kinase signaling, leading to expression of proinflammatory cytokines and chemokines. The G allele of TLR4 rs4986790 (+896A>G, Asp299Gly) gene polymorphism has been implicated in reduction of risk of atherosclerosis. In this study, 1481 RA patients fulfilling the 1987 American College of Rheumatology (ACR) criteria were genotyped for the rs4986790 TLR4 variant to determine the influence of this variant in the risk of CV events in these patients. Also, HLA-DRB1 status was determined using molecular based methods. Moreover, potential influence of rs4986790 variant in the development of subclinical atherosclerosis was assessed in a subgroup of RA patients with no history of CV events by the measurement of surrogate markers of subclinical atherosclerosis. No statistically significant differences in allele or genotype frequencies for the rs4986790 variant between RA patients who experienced CV events or not were found. Likewise, no significant association between this gene variant and any of the surrogate ma...Continue Reading

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Citations

Nov 9, 2012·Journal of Thrombosis and Thrombolysis·Lidio Gonçalves Lima-NetoMario Hiroyuki Hirata
Jan 18, 2013·Rheumatology International·Young Ho LeeGwan Gyu Song
Aug 29, 2012·Mediators of Inflammation·Luis Rodríguez-RodríguezJavier Martín
Jun 21, 2016·Diabetes Research and Clinical Practice·Monika BuraczynskaMichal Dragan
Nov 9, 2016·Vascular Pharmacology·Swati SharmaMohammad Z Ashraf
Jun 20, 2020·International Journal of Rheumatic Diseases·Shunchao YanLinshan Zhao
Jul 23, 2019·Molecular Genetics & Genomic Medicine·Abdelhabib SemlaliMohammad Alanazi

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Methods Mentioned

BETA
genotyping
PCR
dot-blot

Software Mentioned

STATA
CaTS - Power Calculator

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