Lack of association between TNF-α gene promoter polymorphisms and pancreatitis: a meta-analysis

Gene
Zhiping YangDaiming Fan

Abstract

Tumor necrosis factor alpha (TNF-α) is a major proinflammatory cytokine involved in the etiology of pancreatitis. The association between pancreatitis and the -308G>A and -238G>A polymorphisms in TNF-α gene has been analyzed in several studies, but results have been inconsistent. The purpose of this study was to integrate previous findings and explore whether these polymorphisms are associated with susceptibility and severity to pancreatitis. A meta-analysis was performed by searching PubMed, Cochrane Library, and ScienceDirect databases. Data were extracted using predefined form and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Our meta-analysis of a total of 1569 pancreatitis cases and 1330 control subjects from twelve published case-control studies for the -308G>A polymorphism (OR 0.98; 95% CI 0.83-1.17), and of 480 cases and 302 controls from four studies for the -238G>A polymorphism (OR 0.92; 95% CI 0.58-1.47) did not show any significant associations of susceptibility to pancreatitis with the variant GA+AA genotypes compared with the GG genotype. An association between severity of acute pancreatitis and -308G>A polymorphism was not found either (OR 0.93; 95% CI 0.69-1.24). Polymorphisms in two sites...Continue Reading

References

Mar 20, 2003·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Alexander SchneiderDavid C Whitcomb
Jul 31, 2003·The Journal of Surgical Research·DianLiang ZhangXingMing Tang
May 27, 2005·Journal of Clinical Pathology·W M HowellA C Bateman
Jul 19, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rupjyoti TalukdarRakesh Tandon
Sep 17, 2009·American Journal of Epidemiology·Miguel MarcosFrancisco-Javier Laso

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Citations

Jul 23, 2013·Current Opinion in Gastroenterology·Rawad Mounzer, David C Whitcomb
Nov 8, 2012·Hepatitis Research and Treatment·Sirous Tayebi, Ashraf Mohamadkhani
Aug 27, 2014·Current Problems in Surgery·D Rohan JeyarajahShirali Patel
Dec 28, 2019·Genetic Testing and Molecular Biomarkers·Xiao-Qin ZhangXiao-Bo Huang
Feb 16, 2019·Gastroenterology·Pramod K Garg, Vijay P Singh

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