Lack of association between UBQLN1 and Alzheimer disease

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Michael A SliferM A Pericak-Vance

Abstract

Alzheimer disease (AD) is heterogeneous and complex with a strong genetic diathesis. It is the most common cause of dementia affecting the elderly. Linkage studies [Kehoe et al., 1999; Hum Mol Genet 8: 237-245]; [Pericak-Vance et al., 2000; Exp Gerontol 35: 1343-1352]; [Myers et al., 2002; Am J Med Genet 114: 235-244]; [Blacker et al., 2003; Hum Mol Genet 12: 23-32] identified chromosome 9q as a region containing a possible AD candidate gene. Functional protein studies [Mah et al., 2000; J Cell Biol 151: 847-862]; [Ko et al., 2002; J Biol Chem 277: 35386-35392] identified the UBQLN1 gene on chromosome 9q that encodes ubiquilin as a likely candidate for a role in late-onset AD pathogenesis. A recent family-based study by [Bertram et al., 2005; N Engl J 352: 884-894] reported genetic association and expression evidence for a putative AD risk allele of an intronic single nucleotide polymorphism (SNP) within the UBQLN1 gene. In this study, we comprehensively assessed whether any of seven polymorphisms located across the UBQLN1 gene are associated with AD in another large family-based data set and an independent case-control data set. We found no significant association of AD risk with any of the seven SNPs genotyped (including thos...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Jan 1, 1994·Genetic Epidemiology·D J Schaid, R C Elston
Feb 5, 1999·Human Molecular Genetics·P KehoeM J Owen
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
May 10, 2000·Nature Genetics·D F GudbjartssonA Kong
Jun 8, 2000·Bioinformatics·G R Abecasis, W O Cookson
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Dec 13, 2000·Experimental Gerontology·M A Pericak-VanceJ L Haines
Feb 22, 2002·American Journal of Medical Genetics·Amanda MyersAlison Goate
Dec 20, 2002·Human Molecular Genetics·Deborah BlackerUNKNOWN NIMH Genetics Initiative Alzheimer's Disease Study Group
Jul 23, 2003·Archives of Neurology·Sofia A OliveiraEden R Martin
Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
Oct 11, 2003·American Journal of Human Genetics·Eden R MartinNorman L Kaplan
Oct 23, 2003·Human Molecular Genetics·Yi-Ju LiKathleen A Welsh-Bohmer
Mar 9, 2004·Journal of Alzheimer's Disease : JAD·Leann K MasseyMervyn J Monteiro
Jan 8, 2005·Nurse Researcher·Patriek MistiaenCordula Wagner
Mar 5, 2005·The New England Journal of Medicine·Lars BertramRudolph E Tanzi
Jul 1, 2005·The New England Journal of Medicine·Michael A SliferMargaret A Pericak-Vance
Oct 1, 2004·Nurse Researcher·Patriek MistiaenCordula Wagner

❮ Previous
Next ❯

Citations

Nov 13, 2008·Archives of Neurology·Joseph H LeeUNKNOWN National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
Aug 20, 2011·The Journal of Biological Chemistry·Emily S StierenDarren Boehning
Mar 29, 2014·BMC Evolutionary Biology·Ignacio Marín
Jan 21, 2014·Antioxidants & Redox Signaling·Chris McKinnon, Sarah J Tabrizi
Jun 6, 2009·Ageing Research Reviews·Davide SeripaAlberto Pilotto
Jan 31, 2013·Prion·Amina El AyadiDarren Boehning
May 11, 2007·Experimental Cell Research·Hongmin Wang, Mervyn J Monteiro
Mar 15, 2008·Dementia and Geriatric Cognitive Disorders·Maciej P GolanMaria Barcikowska
Apr 23, 2013·Expert Opinion on Therapeutic Targets·Mari TakaloMikko Hiltunen
Mar 13, 2018·Frontiers in Aging Neuroscience·Subodh Kumar, P Hemachandra Reddy
Oct 20, 2007·Human Molecular Genetics·Atish GangulyMing Guo
Feb 27, 2021·Biochemical Society Transactions·Heather A Baker, Jonathan P Bernardini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

© 2021 Meta ULC. All rights reserved