Lack of association of angiotensin converting enzyme gene polymorphism or serum enzyme activity with coronary artery disease in Japanese subjects

American Journal of Hypertension
T FujimuraY Yamada

Abstract

The association of an insertion/deletion (I/D) polymorphism in the angiotensin converting enzyme (ACE) gene or the serum activity of ACE with coronary artery disease (CAD) was investigated in Japanese men and women. The ACE genotype of 947 CAD subjects who underwent coronary angiography and of 893 control subjects was determined by polymerase chain reaction analysis. No association of the DD genotype or the D allele with CAD was observed in men or women. In a low risk group (defined by a body mass index below the median value and the absence of a history of hypertension, diabetes mellitus, and hypercholesterolemia), there was also no association between the ACE gene polymorphism and CAD. No significant difference in serum ACE activity was detected between CAD subjects and controls of all genotypes or of the same genotype, whereas a significant association was apparent between serum ACE activity and ACE genotype for both CAD subjects and controls among both men and women. These results indicate that the ACE I/D polymorphism and genotype associated variation in serum ACE activity are not risk factors for CAD in Japanese men or women.

Citations

Nov 16, 2004·Journal of Clinical Laboratory Analysis·Tatsuya SakumaMario H Hirata
Feb 22, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·He-Ping LeiXi-Yong Yu
Nov 11, 1999·Current Opinion in Lipidology·J P O'MalleyD R Illingworth
Dec 12, 2001·European Journal of Heart Failure·F Mehraban, J E Tomlinson
Jan 2, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Jean-Claude Lapraz, Kamyar M Hedayat

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