Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects

Human Psychopharmacology
Renan P SouzaJames L Kennedy

Abstract

Abnormal activities of critical antioxidant enzymes and other indices of lipid peroxidation in plasma and red blood cells were detected in patients with schizophrenia. Other results have shown that oxidative stress may be modulated by clozapine. Based on that and some studies already found different clinical relations between reactive oxygen species and negative and positive symptoms, we evaluated association between clinical response and the polymorphism in the human glutathione peroxidase (GPX1) (Pro200Leu, rs1050450) and manganese SOD (MNSOD) (Ala16Val, rs4880) gene in 216 clozapine-treated patients with schizophrenia. No association was found with these two functional polymorphisms and clozapine response and symptom change after 6 months. No correlations were found between positive/negative symptoms score and both polymorphisms. Our results present that GPX1 (Pro200Leu) and MNSOD (Ala16Val) polymorphisms seem do not play a central role in the clozapine response, although studies in larger and independent samples are necessary to confirm our findings.

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Citations

Dec 18, 2013·Pharmacogenomics·Evangelia Eirini TsermpiniGeorge P Patrinos
Sep 4, 2010·Neurochemistry International·Tomomi Morikawa, Takayuki Manabe
Apr 7, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amaya BustoJames L Kennedy
Feb 11, 2015·International Journal of Psychiatry in Clinical Practice·Mujgan CengizNese Kocabasoglu
Oct 22, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Fabiana Barzotti Kohlrausch
Aug 11, 2018·Frontiers in Psychiatry·Ruta SamanaiteAlice Egerton
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Narjes HendoueiFatemeh Shaki

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