Lack of association of the dopamine transporter gene in a French ADHD sample

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
M WohlD Purper-Ouakil

Abstract

Discrepancies in the role of the 40 bp VNTR polymorphism of the dopamine transporter gene (DAT1) in attention-deficit hyperactivity disorder (ADHD) could be due to various sources of genetic or phenotypical heterogeneity. We therefore analyzed a sample of 146 ADHD children and their parents, with a transmission disequilibrium test (TDT) design, assessing age, inattention, and hyperactivity dimensions and total score of the ADHD Rating Scale, the number of errors and the total score at Stroop Color-Word test, and the total score at the Trail Making Test. The TDT for 10-repeat (10-R) allele shows a perfect lack of transmission bias (Mc Nemar chi(2) = 0) and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes. Lack of statistical power is always a possibility, but with a sample size above the average of the majority of previous studies, and an odds ratio (number of transmitted versus untransmitted 10-R allele) of 1.00 exactly, this possibility may be considered as not very likely.

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Citations

Mar 17, 2011·European Archives of Psychiatry and Clinical Neuroscience·Oussama Kebir, Ridha Joober
Jun 1, 2010·Médecine sciences : M/S·Diane Purper-OuakilMichel Simonneau
Dec 14, 2012·Psychological Reports·Roberto E MercadilloFernando A Barrios
Sep 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Júlia P GenroMara H Hutz
Aug 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nanda N J RommelseJaap Oosterlaan
Jul 16, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ning JiYu-feng Wang
Apr 24, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Z HawiM Gill
Aug 31, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chi-Yung ShangHai-Gwo Hwu
Nov 4, 2008·Medicine, Health Care, and Philosophy·Timothy Krahn
Apr 7, 2010·Expert Review of Neurotherapeutics·Júlia P GenroMara H Hutz

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