Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.

PloS One
Christiane WinklerAnette-Gabriele Ziegler

Abstract

To investigate whether type 2 diabetes susceptibility genes and body weight influence the development of islet autoantibodies and the rate of progression to type 1 diabetes. Genotyping for single nucleotide polymorphisms (SNP) of the type 2 diabetes susceptibility genes CDKAL1, CDKN2A/2B, FTO, HHEX-IDE, HMGA2, IGF2BP2, KCNJ11, KCNQ1, MTNR1B, PPARG, SLC30A8 and TCF7L2 was obtained in 1350 children from parents with type 1 diabetes participating in the BABYDIAB study. Children were prospectively followed from birth for islet autoantibodies and type 1 diabetes. Data on weight and height were obtained at 9 months, 2, 5, 8, 11, and 14 years of age. None of type 2 diabetes risk alleles at the CDKAL1, CDKN2A/2B, FTO, HHEX-IDE, HMGA2, IGF2BP2, KCNJ11, KCNQ1, MTNR1B, PPARG and SLC30A8 loci were associated with the development of islet autoantibodies or diabetes. The type 2 diabetes susceptible genotype of TCF7L2 was associated with a lower risk of islet autoantibodies (7% vs. 12% by age of 10 years, P = 0.015, P(corrected) = 0.18). Overweight children at seroconversion did not progress to diabetes faster than non-overweight children (HR: 1.08; 95% CI: 0.48-2.45, P>0.05). These findings do not support an association of type 2 diabetes ri...Continue Reading

References

Jul 31, 2001·Lancet·M A Atkinson, G S Eisenbarth
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Jan 31, 2006·Diabetes Care·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study Group
Aug 19, 2007·Nature Reviews. Genetics·Timothy M Frayling
Sep 14, 2007·Pediatric Diabetes·UNKNOWN TEDDY Study Group
Jul 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Christiane WinklerAnette-Gabriele Ziegler
May 13, 2010·Diabetes·Christiane WinklerAnette-Gabriele Ziegler
Jun 29, 2010·Nature Genetics·Benjamin F VoightUNKNOWN GIANT Consortium
Sep 28, 2010·Diabetologia·M SchlosserUNKNOWN Participating Laboratories

❮ Previous
Next ❯

Citations

Jul 10, 2013·Nature Reviews. Endocrinology·Lício A VellosoMiriam Cnop
Mar 15, 2013·Trends in Endocrinology and Metabolism : TEM·Yumi ImaiJerry L Nadler
Sep 13, 2014·International Journal of Endocrinology·Włodzimierz LuczyńskiArtur Bossowski
Jul 31, 2018·Current Diabetes Reviews·Mette Korre Andersen, Torben Hansen
May 9, 2016·Diabetologia·Yahui KongLaura C Alonso
May 26, 2016·Diabetes Care·John P KirwanPhilip R Schauer
Mar 8, 2016·Diabetes/metabolism Research and Reviews·Włodzimierz ŁuczyńskiArtur Bossowski

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS
Statistical Package for the Social Sciences ( SPSS

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.