PMID: 7536230Jan 1, 1995Paper

Lack of augmenting effect of interferon-gamma on dengue virus multiplication in human peripheral blood monocytes

Journal of Medical Virology
N SittisombutJ Supawadee

Abstract

The effect of interferon-gamma (IFN-gamma) on dengue virus multiplication in human peripheral blood monocytes was investigated. Enriched monocytes were treated with IFN-gamma and then infected with dengue virus type 2 either directly or in the presence of optimal infection-enhancing levels of antibodies. Pretreatment of monocytes from dengue-immune donors with 100 IU/ml of IFN-gamma caused 12- to 97-fold and 13- to 137-fold reduction of virus yields at 24 hr after infection in the absence and presence of an anti-flavivirus monoclonal antibody, respectively. IFN-gamma also diminished virus yields when infection of monocytes from a donor who lacked anti-dengue antibody was enhanced 40-fold. The percentage of infected monocytes in IFN-gamma-pretreated cultures was similarly reduced. Dominance of the antiviral effect of IFN-gamma in monocytes is in contrast to an augmenting effect previously observed in the promonocytic cell line U937.

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Citations

Feb 13, 2001·Journal of Virological Methods·R SriburiN Sittisombut
Feb 14, 2004·Journal of Virology·Poonsook KeelapangNopporn Sittisombut
May 30, 2013·PloS One·Tanu ChawlaEng Eong Ooi
Jan 10, 2018·Biomolecules & Therapeutics·Mee Sook ParkMan-Seong Park
Jan 15, 2011·Antiviral Chemistry & Chemotherapy·Justin G JulanderSujan Shresta
Jan 27, 2004·The American Journal of Tropical Medicine and Hygiene·William GwinnAlan D King
Nov 1, 2016·Expert Review of Anti-infective Therapy·Esther Shuyi GanKuan Rong Chan
Aug 20, 2010·Journal of Proteome Research·Rattiyaporn KanlayaVisith Thongboonkerd

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