PMID: 9533418Apr 9, 1998Paper

Lack of autonomic contributions to tonic nitric oxide-mediated vasodilatation in unanesthetized free-moving rats

Journal of Hypertension
A RadaelliA U Ferrari

Abstract

To clarify the controversial issue of whether autonomic influences modulate vascular nitric oxide-mediated vasodilatation or even directly contribute to production of nitric oxide (NO) via nitroxidergic fibers. Chronic venous and arterial catheters were implanted in Wistar-Kyoto rats (n = 65) for continuous blood pressure measurement, drug administration and blood sampling. Tonic NO-dependent vasodilatation in the conscious free-moving animal was evaluated as the pressor response to inhibition of NO synthesis by intravenous L-monomethylarginine (a 100 mg/kg intravenous bolus plus 0.5 mg/kg per min infusion for 30 min). Experiments were performed under control conditions, chemical sympathectomy by 6-hydroxy-dopamine, ganglionic blockade by hexamethonium, and surgical denervation of sino-aortic baroreceptors. Baseline mean arterial pressure was 100+/-4 mmHg (mean +/- SEM) in control rats and 73+/-3, 62+/-5, and 105+/-10 mmHg in sympathectomized, ganglion-blocked, and denervated rats, respectively. The peak increase in mean arterial pressure after administration of L-monomethylarginine was 38+/-3 mmHg in control rats and 51+/-3, 50+/-6, and 63+/-10 mmHg in sympathectomized, ganglion-blocked, and denervated rats, respectively. Epin...Continue Reading

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Citations

Dec 7, 2006·Current Hypertension Reports·Simon C MalpasCarolyn J Barrett
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Sarah-Jane GuildSimon C Malpas
Feb 23, 2008·American Journal of Hypertension·Andrea L FelletAna M Balaszczuk
Mar 29, 2008·American Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Apr 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A L FelletA M Balaszczuk
Jun 18, 1999·Hypertension·H M StaussP B Persson
Jan 29, 2002·Journal of Cardiovascular Pharmacology·A U FerrariG Mancia
May 11, 2001·Journal of Cardiovascular Pharmacology·P BousquetJ Feldman
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·M Sander, R G Victor
Dec 23, 1999·Journal of Hypertension·J BlancB Jover
Oct 12, 1999·The American Journal of Physiology·W I SivitzW G Haynes
Apr 13, 2004·Journal of Cardiovascular Pharmacology·Laurent MonassierPascal Bousquet
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K ThomsenM Lauritzen

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