PMID: 6539423Mar 15, 1984Paper

Lack of carcinogenicity of agaritine by subcutaneous administration in mice

Mycopathologia
B Toth, H Sornson

Abstract

Agaritine (A), an ingredient of the cultivated mushroom of commerce Agaricus bisporus, was administered by subcutaneous injection to two groups of randomly bred Swiss mice. In the first group the animals of both sexes were treated at a 100 micrograms/g body weight basis five times at weekly intervals, while in the second group the mice received a single A treatment of 100 micrograms/g body weight for females and 50 micrograms/g body weight for males. The administration of the compound resulted in no detectable carcinogenic effect in the animals. Since some of the breakdown products of A were shown to be carcinogenic in mice and the mushroom itself was found to be mutagenic, the field is discussed in the light of the obtained results.

References

Jan 1, 1974·Journal of the National Cancer Institute·B Toth, H Shimizu
Dec 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A E RossB Toth
Dec 1, 1982·Mutation Research·E G RoganB Toth

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Citations

Nov 1, 1993·Mycopathologia·B Toth, P Gannett
Mar 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A GrüterF E Würgler
Aug 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C Papaparaskeva-PetridesR Walker
Jul 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J PriceB G Lake
Nov 29, 2002·Food Additives and Contaminants·J HajslováH C Andersson
Jul 8, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Ying LiuMasuro Motoi
Feb 24, 2009·BMC Immunology·Sanhong YuMargherita T Cantorna
May 18, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Satoshi OhnoMasaki Inoue
Mar 9, 2011·Biochimica Et Biophysica Acta·Hidehiko AkiyamaHidehiko Beppu
Aug 21, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I P LeeJ R Kim
Aug 31, 2000·Nutrition and Cancer·K WaltonC Ioannides

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