Lack of carcinogenicity of medium-viscosity liquid paraffin given in the diet to F344 rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T ShodaM Takahashi

Abstract

The carcinogenicity of medium-viscosity liquid paraffin was examined in Fischer 344 rats. Groups of 50 males and 50 females were given the material at dietary doses of 0 (control), 2.5 or 5% for 104 wk. Slight increases in food consumption and body weight were observed in both sexes of the 5% group. However, no significant differences between the control and treated groups were noted with regard to clinical signs, mortality and haematology findings. A variety of tumours developed in all groups, including the control group, but all the neoplastic lesions were histologically similar to those known to occur spontaneously in F344 rats, and no statistically significant increase in the incidence of any tumour type was found for either sex in the treated groups. Granulomatous inflammation in the mesenteric lymph nodes, considered to be a reaction to paraffin absorption, was observed with similar incidence and severity in both sexes of the 2.5 and 5% groups. Thus, it is concluded that under the present experimental conditions, the high dose, about 2000-200,000 times higher than the current temporary acceptable daily intake, does not have any carcinogenic potential in F344 rats. Furthermore, granulomatous inflammation observed in mesent...Continue Reading

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Citations

Jul 24, 2001·Archives of Disease in Childhood·F SharifB Bourke
Oct 27, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L C GriffisJ Rojko
Oct 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mico IkedaKatsumi Imaida
Feb 6, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K KurodaT Umemura
May 15, 2013·Regulatory Toxicology and Pharmacology : RTP·Anette ThielJerrold M Ward
Feb 11, 2015·Regulatory Toxicology and Pharmacology : RTP·Julie A SkareCarol Eisenmann
Mar 17, 2012·International Journal of Toxicology·Richard H McKeeMary Jo Miller
Sep 22, 2018·International Journal of Toxicology·Ivan BoyerBart Heldreth
Jan 16, 2020·Critical Reviews in Toxicology·Ralph PirowAndreas Luch
Jan 18, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx
Nov 22, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R BevanD Mitchell

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