PMID: 2105823Jan 15, 1990Paper

Lack of change in striatal DARPP-32 levels following nigrostriatal dopaminergic lesions in animals and in parkinsonian syndromes in man

Brain Research
Rita Raisman-VozariY Agid

Abstract

The present study was performed to determine the effect of a nearly complete nigrostriatal dopaminergic denervation on DARPP-32 levels in the striatum from animals and parkinsonian patients. DARPP-32 levels were estimated by in vitro phosphorylation in the presence of cAMP, or after inactivation of endogenous kinases and phosphatases, in the presence of the catalytic subunit of cAMP-dependent protein kinase. Intranigral 6-hydroxydopamine (6-OHDA) infusion in rats, or peripheral administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to common marmosets, did not change striatal DARPP-32 levels. Postmortem studies, carried out on brains obtained shortly after death, from patients with Parkinson disease, or from patients with progressive supranuclear palsy, showed that the levels of striatal DARPP-32 were not different from controls. These results indicate that dopaminergic striatal denervation did not modify the amount of DARPP-32 in the striatum, suggesting that the expression of DARPP-32, a protein which mediates some of the effects of dopamine in striatal neurons, is independent from the dopaminergic innervation.

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Citations

May 30, 2013·Journal of Neural Transmission·Hideki HayakawaYoshikuni Mizuno
Aug 1, 1996·European Journal of Pharmacology·P J BlanchetD R Britton
Oct 5, 2011·Pharmacological Reviews·Maryka Quik, Susan Wonnacott
Oct 22, 2008·Brain Research·Laura M HarrisonDavid N Ruskin
Sep 16, 2008·Molecular and Cellular Neurosciences·Marie WesterlundDagmar Galter
Jun 14, 2003·The Veterinary Record·A RaoofiS Nekoei

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