The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin and gastrin levels. Acute pentagastrin injection in normal male subjects increased significantly (P less than 0.05) plasma calcitonin levels whereas lower doses of pentagastrin which are known to stimulate gastric secretion are without effect on calcitonin levels. Moreover, stimulation of gastrin secretion by a protein test meal and by intragastric administration of a calcium chloride solution is not followed by any significant increase of plasma calcitonin levels. These results suggest that the stimulation of calcitonin secretion by gastrin and its synthetic analogue pentagastrin is a pharmacological rather than a physiological phenomenon.
Comparison of the effects of pentagastrin and meal-stimulated gastrin on plasma calcitonin in normal man
Regulation of calcitonin secretion in normal man by changes of serum calcium within the physiologic range
Stimulation of gastrin secretion in the pig by parathyroid hormone and its inhibition by thyrocalcitonin
Changes in histologic and biochemical indexes of bone turnover after bilateral nephrectomy in patients on hemodialysis. Evidence for a possible role of endogenous calcitonin
Calcitonin secretion by monolayer cultures of human C-cells derived from medullary thyroid carcinoma
Calcitonin secretion in vitro. II. Regulatory effects of enteric mammalian polypeptide hormones on trout C-cell cultures
A comparison of pentagastrin injection and calcium infusion as provocative agents for the detection of medullary carcinoma of the thyroid
Relations of calcitonin and gastrin in the Zollinger-Ellison syndrome and medullary carcinoma of the thyroid
The role of serum gastrin in the secretion of calcitonin: studies in patients with pernicious anaemia and in healthy subjects
Diurnal patterns of serum immunoreactive calcitonin in healthy males and in insulin dependent diabetics
Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.