Lack of clinical and physiological relationship between gastrin and calcitonin in man

European Journal of Clinical Investigation
G HeynenP Franchimont

Abstract

The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin and gastrin levels. Acute pentagastrin injection in normal male subjects increased significantly (P less than 0.05) plasma calcitonin levels whereas lower doses of pentagastrin which are known to stimulate gastric secretion are without effect on calcitonin levels. Moreover, stimulation of gastrin secretion by a protein test meal and by intragastric administration of a calcium chloride solution is not followed by any significant increase of plasma calcitonin levels. These results suggest that the stimulation of calcitonin secretion by gastrin and its synthetic analogue pentagastrin is a pharmacological rather than a physiological phenomenon.

References

Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·S A MetzR P Robertson
Feb 15, 1975·Lancet·M Telenius-BergB Wästhed
Jul 1, 1977·Endocrinology·C W CooperD A Ontjes
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J G Parthemore, L J Deftos
Dec 1, 1978·The American Journal of Digestive Diseases·C OwyangV L Go
Dec 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·J F Obie, C W Cooper
Sep 1, 1977·Acta Endocrinologica·J FahrenkrugJ F Rehfeld
Dec 1, 1977·The Journal of Endocrinology· Garel J-M, A Jullienne
Apr 1, 1977·Clinical Endocrinology·C J HillyardI Macintyre
Nov 1, 1977·The Journal of Clinical Investigation·H Heath, G W Sizemore
Mar 29, 1973·The New England Journal of Medicine·G W SizemoreC D Arnaud
Jun 1, 1974·European Journal of Clinical Investigation·G Heynen, P Franchimont
Jun 1, 1972·The Journal of Endocrinology·M PhillippoD R Donaldson
Jun 18, 1971·Science·C W CooperD A Ontjes
Oct 24, 1969·Science·P L Gray TKMUNSON
Apr 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Kraml
Jan 29, 1981·The New England Journal of Medicine·L A Austin, H Heath

❮ Previous
Next ❯

Citations

Mar 1, 1988·Peptides·E BuchtH E Sjöberg
Nov 23, 2006·Journal of Endocrinological Investigation·M F ErdoganM Kulaksizoglu
Mar 1, 1991·Acta Physiologica Scandinavica·N A al-FalaheA B Vallbo
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel
Jun 1, 1989·Journal of Endocrinological Investigation·M PedrazzoniM Passeri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

© 2021 Meta ULC. All rights reserved