Lack of Conclusive Evidence of the Benefit of Biologic Augmentation in Core Decompression for Nontraumatic Osteonecrosis of the Femoral Head: A Systematic Review.

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Octavian AndronicPatrick O Zingg

Abstract

To assess whether biologic augmentation in addition to core decompression (CD), compared with CD alone, improves clinical and radiographic outcomes in the treatment of nontraumatic osteonecrosis of the femoral head (ONFH). Our hypothesis was that biologic augmentation would reduce the progression of osteonecrosis and therefore also the rate of conversion to total hip arthroplasty (THA). A systematic review was performed in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) statement. Six databases were searched: Central, MEDLINE, Embase, Scopus, AMED, and Web of Science. Studies comparing outcomes of CD versus CD plus biologic augmentation (with or without structural augmentation), with a reported minimum level of evidence of III and ≥24 months of follow-up, were eligible. Procedural success was conceptualized as (1) avoidance of conversion to THA and (2) absence of radiographic disease progression. Risk of bias was assessed using the Joanna Briggs Institute critical appraisal checklists. A quantitative analysis of heterogeneity was undertaken. We included studies reporting on 560 hips in 484 patients. Biologic augmentation consisted of bone marrow stem cells in 10 studies, bone morph...Continue Reading

References

May 12, 2001·Clinical Orthopaedics and Related Research·M E SteinbergK E Hartman
Dec 4, 2002·Clinical Orthopaedics and Related Research·Philippe Hernigou, Françoise Beaujean
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jul 24, 2004·The Orthopedic Clinics of North America·Matthew J GarberinaJames R Urbaniak
Aug 1, 2006·The Journal of Arthroplasty·Nelson Fong SoohooJay R Lieberman
Mar 11, 2008·Clinical Orthopaedics and Related Research·Yoichi Sugioka, Takuaki Yamamoto
Oct 6, 2009·Orthopaedics & Traumatology, Surgery & Research : OTSR·M Mukisi-MukazaF Burny
Aug 10, 2011·Laboratory animal research·Yawon HwangGonhyung Kim
Nov 25, 2014·European Heart Journal·Bruno R da Costa, Peter Juni
Jan 1, 2010·Research Synthesis Methods·Judith Anzures-Cabrera, Julian P T Higgins
Jul 6, 2015·Current Reviews in Musculoskeletal Medicine·Kalpit N ShahRoy K Aaron
Jul 14, 2016·BMJ Open·Joanna IntHoutJelle J Goeman
May 17, 2017·The Journal of Bone and Joint Surgery. American Volume·Iain R MurrayRobert F LaPrade
Jan 3, 2018·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Xiao YuQingjiang Pang
Dec 5, 2018·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Mark P CoteJefferson C Brand
Apr 18, 2019·EFORT Open Reviews·Daniel PetekDomizio Suva
Feb 6, 2020·EFORT Open Reviews·Bülent AtillaJavad Parvızı
Aug 11, 2020·JAMA Surgery·Ahmed K EmaraNicolas S Piuzzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.