Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.

Mechanisms of Ageing and Development
Alan A CohenTamàs Fülöp

Abstract

At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as the essence of aging, when it begins, whether aging is programmed or not, whether we currently have a good understanding of aging mechanisms, whether aging is or will be quantifiable, whether aging will be treatable, and whether many non-aging species exist. These disagreements lay bare the urgent need for a more unified and cross-disciplinary paradigm in the biology of aging that will clarify both areas of agreement and disagreement, allowing research to proceed more efficiently. We suggest directions to encourage the emergence of such a par...Continue Reading

References

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Sep 20, 2020·Mechanisms of Ageing and Development·Alan A CohenTamàs Fülöp

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Citations

Sep 20, 2020·Mechanisms of Ageing and Development·Alan A CohenTamàs Fülöp
Oct 9, 2020·Mechanisms of Ageing and Development·Jean-François LemaîtreJean-Michel Gaillard
Sep 20, 2020·Mechanisms of Ageing and Development·Graham PawelecAlan A Cohen
Dec 16, 2020·Antioxidants·Leopold Flohé
Mar 7, 2021·Cells·Giulietta Di BenedettoKonstantinos Lefkimmiatis
Apr 6, 2021·Mechanisms of Ageing and Development·Alan A Cohen, Tamàs Fülöp
Jun 7, 2021·Biogerontology·Aleksei G Golubev
Jun 4, 2021·Ageing Research Reviews·Fabiola OlivieriMassimiliano Bonafè
Aug 16, 2021·Ageing Research Reviews·Aurelia SantoroDaniela Monti
Sep 19, 2021·Clinical Reviews in Allergy & Immunology·T FulopC Franceschi
Sep 21, 2021·Aging·Alibek MoldakozhayevVadim N Gladyshev

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