Lack of correlation between arterial and venous beta-adrenergic receptor sensitivity

Hypertension
C M SteinA J Wood

Abstract

The regulation of vascular beta-adrenoceptor responses in humans has been studied in vivo in both arteries and veins. Because venous responses can be studied less invasively than arterial responses, they are an attractive substitute for the measurement of arterial responses, provided that venous responses are representative of responses in resistance arteries. However, although venous, particularly hand vein response, has been extensively studied, arterial and venous beta-adrenergic sensitivities, in the same individuals, have not been compared. Measures of venous and arterial beta-adrenergic sensitivities were compared in 10 healthy normotensive subjects. Forearm blood flow, after administration of increasing doses of isoproterenol into the brachial artery, was measured by strain-gauge plethysmography and was used for determination of arterial beta-adrenoceptor sensitivity, expressed as the IP500 (the dose of isoproterenol resulting in a fivefold [500%] increase in baseline forearm blood flow). Venous sensitivity to isoproterenol, expressed as the IP15 (the dose of isoproterenol resulting in 15% venodilation), was measured in a dorsal hand vein using the linear variable differential transformer. Administration of isoproterenol...Continue Reading

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Citations

Oct 12, 2000·Journal of the American College of Cardiology·B J KnealeJ M Ritter
Jul 29, 2010·Clinical and Experimental Hypertension : CHE·Maple M FungDaniel T O'Connor
Feb 26, 1999·The American Journal of the Medical Sciences·D H Streeten
Nov 14, 2008·International Journal of Cardiology·Pawan D PatelRohit R Arora
Nov 14, 1997·Clinical Pharmacology and Therapeutics·C M SteinA J Wood
Mar 12, 1999·British Journal of Clinical Pharmacology·S ChalonB B Hoffman

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