PMID: 8586817Sep 1, 1995Paper

Lack of correlation between microalbuminuria and endothelial function in essential hypertensive patients

Journal of Hypertension
S TaddeiA Salvetti

Abstract

To evaluate whether microalbuminuria, defined as urinary albumin excretion between 30 and 300 mg/24 h, is associated with endothelial dysfunction in essential hypertensive patients. We correlated urinary albumin excretion with vasodilatation in response to endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) agonists in the forearm vascular bed in essential hypertensive patients with (n = 13) and without (n = 23) microalbuminuria and matched normotensive controls (n = 21). We studied forearm vascular responses (strain-gauge plethysmography) to intrabrachial infusion of acetylcholine (0.15, 0.45, 1.5, 4.5 and 15 ng/100 ml forearm tissue/min) and of sodium nitroprusside (1, 2, 4ng/100 ml forearm tissue per min). Minimal forearm vascular resistances (the ratio between mean arterial pressure and maximal forearm vasodilation induced by 13 min of ischaemia + 1 min of exercise) were also evaluated. Responses to acetylcholine, but not to sodium nitroprusside, were significantly blunted and minimal forearm vascular resistances were increased in hypertensive patients compared with controls. However, no correlation was found between urinary albumin excretion and vasodilatation in response to acetylcholine or to so...Continue Reading

Citations

Apr 8, 1998·Current Opinion in Nephrology and Hypertension·A Mimran
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·A MimranG Du Cailar
Jun 15, 2000·Blood Pressure·L LindJ Millgård
Sep 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Peter TothIstvan Wittmann
Dec 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S BianchiV M Campese
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joshua I BarzilayDavid M Herrington
Sep 13, 2015·BMC Research Notes·Hilal Bahjet Al-SaffarSebastian Philipp
Nov 13, 2009·Diabetes Care·Daniele VersariStefano Taddei
Apr 18, 2002·Vascular Medicine·R PedrinelliM Mariani
Jan 27, 2018·Journal of Hypertension·Remy J H MartensCoen D A Stehouwer
Oct 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Roberto PedrinelliGiuseppe Penno
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Peter OchodnickyDick de Zeeuw
Jan 22, 2005·Journal of Hypertension·Enrico Agabiti RoseiUNKNOWN CENTRO (CandEsartaN on aTherosclerotic Risk factors) study investigators
Jul 1, 1997·Clinical and Experimental Hypertension : CHE·A Mimran
Apr 30, 2015·Journal of Hypertension·Stefano Taddei, Rosa Maria Bruno

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