Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila

Annals of the New York Academy of Sciences
Satomi MiwaMartin D Brand

Abstract

The free radical theory of aging proposes that mitochondrial production of reactive oxygen species (ROS) determines the rate of aging. Supporting this hypothesis, longer-lived species produce fewer ROS than shorter-lived ones, and calorically restricted rodents live longer and produce fewer ROS than controls. We studied such correlation in Drosophila melanogaster in caloric restriction and in mutant flies overexpressing the mitochondrial adenine nucleotide translocase (ANT). Caloric restriction extended life span, but there was no significant difference in mitochondrial ROS production compared with controls. ANT overexpressers had significantly lower ROS production (because they had lower membrane potential), but their life span was not extended compared to wild type. Our results show two examples in which mitochondrial ROS production and life span are not correlated.

References

Apr 30, 1990·Mechanisms of Ageing and Development·R S SohalU T Brunk
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Jul 5, 1996·Science·R S Sohal, R Weindruch
Feb 3, 1999·Annals of the New York Academy of Sciences·G Barja
Oct 15, 2003·Free Radical Biology & Medicine·Satomi MiwaMartin D Brand

❮ Previous
Next ❯

Citations

May 30, 2006·Biogerontology·Bart P BraeckmanJacques R Vanfleteren
Sep 1, 2005·Age·Ronny HaenoldToshinori Hoshi
Jun 7, 2005·Mechanisms of Ageing and Development·Linda PartridgeWilliam Mair
Feb 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Viviana I PérezAsish Chaudhuri
Oct 7, 2008·The Journal of Biological Chemistry·Young Min ChungYoung Do Yoo
Jul 12, 2013·Antioxidants & Redox Signaling·Jose ViñaMari Carmen Gomez-Cabrera
Feb 4, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tapiwanashe MagwereLinda Partridge
Sep 27, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Oge Arum, Thomas E Johnson
Oct 5, 2007·Nucleic Acids Research·Jian-Hua ChenSusan E Ozanne
Apr 1, 2008·Annual Review of Biochemistry·William Mair, Andrew Dillin
Aug 22, 2007·PloS One·Martin WeinbergerWilliam C Burhans
Jun 2, 2011·Journal of Aging Research·Tina Wenz
Apr 7, 2010·Mechanisms of Ageing and Development·Shona A MookerjeeMartin D Brand
Mar 12, 2010·Mechanisms of Ageing and Development·Melissa M PageJeffrey Alan Stuart
Nov 3, 2009·Urologic Oncology·PierFrancesco Bassi, Emilio Sacco
Aug 8, 2007·Insect Biochemistry and Molecular Biology·Subhash D Katewa, J William O Ballard
Feb 17, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alan CohenRobert Ricklefs
Jan 30, 2008·Journal of Internal Medicine·A Trifunovic, N-G Larsson
Apr 23, 2014·Geriatrics & Gerontology International·Ye LiuJiankang Liu
Sep 3, 2005·Experimental Gerontology·Matthew D W PiperLinda Partridge
May 17, 2005·Mechanisms of Ageing and Development·David A Sinclair
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Alicia J Kowaltowski
Apr 17, 2012·Ageing Research Reviews·David Clancy, John Birdsall
Apr 13, 2010·Environmental Pollution·Miia J Koivula, Tapio Eeva
Apr 1, 2006·Biochimica Et Biophysica Acta·Reinald Pamplona, Gustavo Barja
Aug 30, 2007·Aging Cell·J William O BallardSubhash D Katewa
Oct 18, 2008·Physiology·Wei-Lien Yen, Daniel J Klionsky
Mar 21, 2020·Biochemical Society Transactions·Claudia Lennicke, Helena M Cochemé
Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Frédéric SaldmannGérard Friedlander
May 5, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marte MolenaarsRiekelt H Houtkooper
Sep 28, 2020·Free Radical Biology & Medicine·Chiara H MorettiJon O Lundberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.