Lack of correlation between P-glycoprotein and chemotherapy resistance in nasal NK/T-cell lymphomas

Leukemia & Lymphoma
Gwi Eon KimJee-Sook Hahn

Abstract

Thirty patients with nasal natural killer (NK)/T-cell lymphoma, who underwent systemic chemotherapy with or without involved-field radiotherapy between 1993 and 1998, were retrospectively reviewed to determine the clinical significance of P-glycoprotein immunohistochemically identified in tumor specimens. Eighty percent of previously untreated patients expressed P-glycoprotein. According to P-glycoprotein immunoreactivity, all patients with nasal NK/T-cell lymphoma were divided into 2 groups; (a) P-glycoprotein-negative group (N = 6) and (b) P-glycoprotein-positive group (N = 24). There was no significant difference in clinical profiles between both groups. Regardless of the P-glycoprotein expressions, Epstein-Barr virus genomes were almost identically detected in patients of the 2 groups. Contrary to our expectations, however, P-glycoprotein expressions were not found to be a strong predictor of chemotherapy resistance. Although 2 (33%) of 6 P-glycoprotein-negative patients and 10 (42%) of the 24 P-glycoprotein-positive patients showed a favorable response to systemic chemotherapy, 4 (67%) of 6 P-glycoprotein-negative patients did not achieve complete response (CR) to chemotherapy, which led to an early death, whereas 4 (17%) ...Continue Reading

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Citations

Nov 4, 2009·Leukemia & Lymphoma·Holbrook Kohrt, Ranjana Advani
Sep 29, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Xuejun MaXiaomao Guo
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Mei-Juan HuangYou Lu
Nov 26, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Arzu SaglamAysegul H Uner
Apr 13, 2011·British Journal of Haematology·Claire E DeardenUNKNOWN British Committee for Standards in Haematology
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ye-Xiong LiZi-Hao Yu
Jun 6, 2017·Clinical Medicine Insights. Blood Disorders·Cat HildyardG P Collins
Jun 13, 2021·Leukemia·Hua WangYang Liang

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