PMID: 9553985Apr 29, 1998Paper

Lack of correlation between soluble CD14 and IL-6 in meningococcal septic shock

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
E ArranzJ A Garrote

Abstract

Meningococcal sepsis is a good model to study the dynamic response of cytokines and other soluble factors in vivo in the early stages of the disease. Levels of soluble CD14, interleukin-6 (IL-6), IL-6 receptor (IL-6R), and C-reactive protein (CRP) have been measured in plasma from 26 children with septic shock (nine of whom had disseminated intravascular coagulation) and from ten control children. All samples were collected at the onset, before treatment, and, when possible, 24 and 48 hours later. At admission, patients had significantly higher levels of IL-6 (p < 0.001) and CRP (p < 0.001), and lower levels of IL-6R (p < 0.005) than normal controls. After 24 hours, there was a significant increase of sCD24 (p < 0.05) and CRP (p < 0.001). Although IL-6 showed a progressive decline since the onset, its levels were always higher than controls. There was an inverse correlation between IL-6 and both IL-6R (p < 0.001) and CRP (p < 0.001), probably due to the later increase of CRP. Nevertheless, sCD14 did not correlate with IL-6 levels. We have confirmed the finding of IL-6 as a sensitive and reliable inflammatory marker in septic shock. Moreover, the ratio IL-6/IL-6R may have a prognostic value, given a putative role of IL-6R in mod...Continue Reading

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Citations

Jan 11, 2000·Clinical Microbiology Reviews·M van DeurenJ W van der Meer
Apr 1, 2010·Journal of Inflammation·Alison L HartePhilip G McTernan
Apr 20, 2016·Antimicrobial Agents and Chemotherapy·Nouria BelkacemMuhamed-Kheir Taha
May 18, 2018·Mediators of Inflammation·Michal HolubOndřej Beran

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