Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: the OFELY study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
T R EccleshallD Feldman

Abstract

Previous studies have demonstrated an association between bone mineral density (BMD) and a start codon polymorphism (SCP) of the vitamin D receptor (VDR) gene in pre- and postmenopausal Caucasian and Japanese women. The SCP can be determined by a restriction fragment length polymorphism defined by the FokI restriction endonuclease. VDR alleles containing the FokI site are denoted by f and alleles lacking the site by F. In this study, the association between BMD and the SCP was examined in a group of 174 premenopausal French women who previously had been studied for a relationship between BMD and the VDR BsmI polymorphism. The SCP genotypes of the French women were FF 40%, Ff 44%, and ff 16% and they were independent of the BsmI genotype. BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine, proximal femur, forearm, and total body. In contrast to previous reports, there was no association of BMD with SCP genotype in this group of Caucasian women at any site. We also measured several biochemical indices of calcium homeostasis and bone turnover. We found no statistically significant associations between SCP genotype and calcium, parathyroid hormone, or vitamin D levels. There was a 33.5% higher level of the ske...Continue Reading

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A Eisman
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Peacock
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A KrallB Dawson-Hughes
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G S Cooper, D M Umbach
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C GrossD Feldman
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S S HarrisD Feldman

❮ Previous
Next ❯

Citations

Apr 25, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C ChatzipapasC A Stratakis
Apr 27, 2000·Clinical Genetics·Y Giguère, F Rousseau
Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·Y BanY Ban
Jun 1, 2001·Journal of Endocrinological Investigation·D SheehanK D Cashman
Mar 17, 2004·The Proceedings of the Nutrition Society·Siobhán Cusack, Kevin D Cashman
Nov 5, 2014·Journal of Diabetes and Metabolic Disorders·Zahra MohammadiHamid Reza Barikani
Jul 20, 1999·Current Opinion in Rheumatology·S FerrariJ P Bonjour
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S FerrariJ P Bonjour
Nov 5, 1998·Aging : Clinical and Experimental Research·S FerrariJ P Bonjour
Jul 25, 2000·European Journal of Clinical Investigation·B L LangdahlE F Eriksen
Apr 20, 1999·Genetic Epidemiology·J M ZmudaR E Ferrell
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L GennariM L Brandi
Mar 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalia Garcia-GiraltDaniel Grinberg
May 8, 2004·Journal of Endocrinological Investigation·E VigoC Segura
Dec 21, 2000·Current Rheumatology Reports·R L WolfJ A Cauley
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P R FischerD Feldman
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S K AmesS A Abrams
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·Y BanT Katagiri
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C GrossD Feldman
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven A AbramsKenneth J Ellis
Jul 25, 2000·Thyroid : Official Journal of the American Thyroid Association·Y BanT Katagiri
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arndt VogelMichael P Manns
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Oct 23, 2002·Journal of Applied Physiology·Orie NakamuraKumpei Tokuyama
May 1, 2017·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ahmed Abdulahi AbdurahmanKhadijeh Mirzaei
Apr 6, 1999·The American Journal of Medicine·P J Malloy, D Feldman
Mar 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose M Valdivielso, Elvira Fernandez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
W C Cheng, K S Tsai
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S S HarrisD Feldman
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
N BregenzerT Andus
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
P GarneroP D Delmas
© 2021 Meta ULC. All rights reserved