Lack of correlation of anaemia with splenomegaly and hepatomegaly in Trypanosoma brucei and Trypanosoma congolense infections of rats

Journal of Comparative Pathology
I O Igbokwe, C O Nwosu

Abstract

Isolates of Trypanosoma brucei and Trypanosoma congolense from the blood of cattle were used to infect growing rats. Despite the use of similar infective doses, T. brucei parasitaemia appeared earlier than T. congolense parasitaemia. After the same period of parasitaemia, the degrees of anaemia, splenomegaly and hepatomegaly were similar in both infections. The percentage decrease in packed cell volume was not correlated with splenic and hepatic weights. Neither infection significantly affected the weight gain of the rats. It was concluded that both organisms caused diseases of comparable severity and that the mere enlargement of the spleen and liver made no significant contribution to the development of the anaemia.

References

Dec 1, 1976·Experimental Parasitology·W J Herbert, W H Lumsden

❮ Previous
Next ❯

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.