Lack of correlative enhancement of passive transfer of delayed-type hypersensitivity and antilisterial resistance when using concanavalin A-stimulated primed spleen cells.

Infection and Immunity
R A Barry, D J Hinrichs

Abstract

The adoptive transfer of resistance to Listeria monocytogenes can be significantly enhanced by in vitro incubation of primed murine spleen cells with concanavalin A (ConA) before transfer into syngeneic recipients. The level of transferred resistance, as measured by clearance of infectious organisms, can approach that observed in actively immunized mice. When delayed-type hypersensitivity (DTH) responses of passive transfer recipients were compared, there was no difference in the level of hypersensitivity exhibited by mice receiving either nonstimulated or ConA-stimulated, Listeria-immune spleen cells. In addition, the level of these adoptively transferred responses never approached the level of DTH observed in actively immunized mice. This inability of ConA-stimulated cells to enhance passive DTH in recipient mice was not dependent on the antigenic preparation of Listeria used to elicit the DTH response. Transfer of cultured, ConA-stimulated, Listeria-immune spleen cells did not lead either to specific or to nonspecific suppression of DTH responsiveness in actively immunized mice. These results indicate the possible existence of antigen-specific T-cells subpopulations which, after stimulation with ConA, exhibit differing effic...Continue Reading

References

Jan 1, 1979·Advances in Immunology·I F McKenzie, T Potter
May 1, 1972·The Journal of Experimental Medicine·F C Lane, E R Unanue
May 1, 1969·The Journal of Experimental Medicine·G B Mackaness
May 1, 1982·The Journal of Experimental Medicine·P A Berche, R J North
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

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