Lack of cross-reactivity between aztreonam , a monobactam antibiotic, and penicillin in penicillin-allergic subjects

The Journal of Infectious Diseases
A SaxonN F Adkinson

Abstract

Monobactam antibiotics are a new class of beta-lactam antibiotics. In contrast to penicillins or cephalosporins, monobactams possess a monocyclic beta-lactam structure. IgE or immediate hypersensitivity cross-reactivity between aztreonam (a monobactam) and penicillin was investigated, since this will be an important consideration when therapy is chosen. The maximum concentration of aztreonam reagents not giving false-positive skin tests was determined in normal subjects who were not allergic to penicillin. Subsequently, 41 subjects with IgE antibody to one or more penicillin moieties, as determined by positive skin reactions, were tested with the aztreonam reagents. Thirty-seven of these persons showed no reactivity while four showed equivocal tests. Repeat tests in those four persons were negative to the aztreonam reagents, while their penicillin tests remained unchanged. These in vivo data suggest that there is no cross-reactivity between IgE antibodies to penicillin and aztreonam and provide a basis for investigating the therapeutic use of monobactams in patients who are allergic to penicillin.

Citations

Oct 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·U B SchaadR Kraemer
Dec 13, 2012·Current Allergy and Asthma Reports·Fatima S Khan, Michael E Weiss
Jan 1, 1985·Pharmacology & Therapeutics·R B SykesE A Swabb
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Oct 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G PatriarcaA Milani
May 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BlancaJ Fernandez
Feb 2, 1991·BMJ : British Medical Journal·P HantsonP Mahieu
Oct 1, 1986·Genitourinary Medicine·D T EvansS W Price
Dec 15, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Richard Warrington, Fanny Silviu-Dan
Nov 8, 2008·Médecine et maladies infectieuses·A ChaabaneM Chakroun
Jul 16, 2014·The Lancet Infectious Diseases·Thomas P Van BoeckelRamanan Laxminarayan
Nov 1, 1991·Mayo Clinic Proceedings·N S Brewer, W C Hellinger
Oct 12, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Nov 29, 2005·The Medical Clinics of North America·Roland Solensky
Mar 16, 2005·Toxicology·Antonino RomanoJean-Louis Guéant
Aug 1, 1986·Journal of Clinical and Hospital Pharmacy·A C Lafong, P G Murphy
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Eric A Meier
Apr 1, 1989·The Journal of Allergy and Clinical Immunology·R C LoriaH J Wedner
Feb 8, 1985·The American Journal of Medicine·J G PastorekJ C Crapanzano
Jan 7, 1998·The Annals of Pharmacotherapy·G D WaltonT G Mulpur
Mar 23, 1990·The American Journal of Medicine·H C Neu
Feb 1, 1992·Pediatric Pulmonology·M Boguniewicz, D Y Leung
Aug 16, 2014·Journal of Pharmacy Practice·Adrienne T Terico, Jason C Gallagher
Feb 6, 2009·The Annals of Pharmacotherapy·Jane Frumin, Jason C Gallagher
Nov 7, 2014·Allergy, Asthma & Immunology Research·Min-Hye Kim, Jong-Myung Lee
Oct 17, 2018·Natural Product Reports·Yuan LiuKui Zhu
Nov 1, 1988·Clinical Allergy·M E Weiss, N F Adkinson
Jan 5, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kristen ZeitlerJack Brown
Feb 2, 1991·BMJ : British Medical Journal·U Pedersen-Bjergaard, J Myhre
May 29, 2000·Scandinavian Journal of Infectious Diseases·E Somekh, Z Cordova
Feb 25, 1988·The New England Journal of Medicine·G R Donowitz, G L Mandell
Oct 27, 2016·Current Opinion in Infectious Diseases·Katherine C KonvinseJason A Trubiano
Jun 23, 2016·Cold Spring Harbor Perspectives in Medicine·Karen Bush, Patricia A Bradford
Apr 1, 1990·DICP : the Annals of Pharmacotherapy·T FeketeB Kreter
Apr 1, 1988·Postgraduate Medicine·W O Wagner
Sep 1, 2004·Expert Opinion on Drug Safety·Eunice K H Tan, Clive E H Grattan
Jul 1, 1986·Pharmacotherapy·S J Childs, G P Bodey
Jun 13, 2008·International Journal of Immunopathology and Pharmacology·G PatriarcaE Nucera
Jul 28, 2010·Expert Review of Respiratory Medicine·Michael D Parkins, J Stuart Elborn
Oct 3, 2018·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Richard WarringtonTiffany Wong
Mar 1, 1988·Postgraduate Medicine·A Saxon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

The Journal of Allergy and Clinical Immunology
A SaxonG B Calandra
Reviews of Infectious Diseases
N F AdkinsonE A Swabb
Antimicrobial Agents and Chemotherapy
N F AdkinsonA A Sugerman
© 2021 Meta ULC. All rights reserved