Lack of differences in blood and tissue concentrations of endogenous ethanol in conventional and germfree rats

Alcohol
A W JonesT Midtvedt

Abstract

Headspace gas chromatography was used to determine the concentrations of endogenous ethanol in blood and tissue of conventional and germfree rats. In all biological specimens analysed, the four principal volatile endogenous substances were identified as methanol, acetaldehyde, ethanol and acetone. No statistically significant differences in the concentrations of endogenous ethanol were noted between conventional and germfree animals. In whole blood, liver, kidney, and brain of germfree rats the concentrations of endogenous ethanol were 4.2 +/- 0.19 microM, 5.1 +/- 0.55 microM, 8.2 +/- 0.59 microM and 4.4 +/- 0.17 microM (means +/- SE), respectively. The higher concentration in kidney was also observed in conventional rats. Our results suggest that ethanol is a normal metabolic intermediate in rats and does not exclusively arise from microbial fermentation reactions in the gastrointestinal tract.

References

Jul 1, 1970·The Biochemical Journal·H A Krebs, J R Perkins
May 22, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·R Blomstrand
May 26, 1966·Biochimica Et Biophysica Acta·I R McManusR E Olson
Jan 1, 1982·Critical Reviews in Toxicology·C Melchior, M A Collins
Jan 1, 1980·Alcoholism, Clinical and Experimental Research·C J Eriksson
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·A W JonesE Anggård
Jan 1, 1958·Acta Pharmacologica Et Toxicologica·F LUNDQUIST, H WOLTHERS
May 8, 1959·Annals of the New York Academy of Sciences·B E GUSTAFSSON

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Citations

Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·A E MedvedevV Glover
Jul 1, 1989·Alcohol·R Alvarado, P Peñafiel
Apr 22, 2004·Drug and Alcohol Dependence·Peter R Giancola
Oct 27, 2004·International Journal of Pharmaceutics·Angelica VargasFlorence Delie
Sep 8, 2000·Medicine, Science, and the Law·B K Logan, A W Jones
Feb 16, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gunda MillonigWolfgang Vogel

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