Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study

The Veterinary Journal
L SebbagG Ben-Shlomo

Abstract

Spontaneous chronic corneal epithelial defects (SCCEDs) are characteristic ulcers in dogs that are refractory to healing. The aim of the study was to evaluate the use of a topical regenerative agent to promote healing of SCCEDs. Nineteen dogs (20 eyes) were randomized to receive either regenerative agent (10 eyes) or placebo (10 eyes) every 48h following corneal debridement, which was repeated 1 week later if the SCCED had not yet healed. The mean±standard deviation time to re-epithelialization was 17.3±12.8 days for the group treated with a topical regenerative agent and 19.3±11.7 days for the group treated with a placebo; the cumulative healing rates were not statistically different (P>0.650). A positive association was found between the initial size of the ulcer and the time to re-epithelialization (r=0.555, P=0.011). Although well tolerated by dogs, there was no therapeutic advantage in using a topical regenerative agent for re-epithelialization of SCCEDs.

Citations

Dec 19, 2019·Veterinary Sciences·Jessica A MartinezDenis Barritault
Apr 24, 2020·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Vera J S PruchaBarbara Nell
Oct 4, 2019·Scientific Reports·Joon Young KimJong Soo Jeon
Nov 6, 2020·Veterinary Ophthalmology·Shayna LevittLynne S Sandmeyer

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