Abstract
Acute ischemic renal failure is of great clinical importance because of its frequent occurrence and the high mortality it causes. Recent observations indicate that reperfusion has its own dangers because of oxygen-derived free radicals. To study this problem, ischemia was evoked in dogs in one kidney, by clamping the left renal artery for 45 min. This was followed by a 90-min period of reperfusion when diuresis, GFR, PAH clearance and sodium and potassium excretion were studied. Besides a control group (n = 6), the following treatment groups were investigated. Allopurinol (n = 7): 50 mg/kg for two days p.o. and 50 mg/kg in physiological saline infusion during the experiment; a small dose of SOD (n = 6): 0.5 mg/kg in infusion, started 1 min before reperfusion and given continuously for 10 min; and a high dose of SOD (n = 7): 5 mg/kg as above. In the first 15 min following reperfusion, the renal functions significantly worsened in all groups. Later on, the renal functions gradually improved and in the last period after reperfusion, GFR in the ischemic kidney was 64%, cPAH 59%, diuresis 60% and sodium and potassium excretion were 65% and 76%, respectively, of the basal values in the control group. Treatment with free radical scave...Continue Reading
References
Dec 1, 1989·Annals of Internal Medicine·M V Cohen
May 1, 1989·The Journal of Surgical Research·J A GalatR S Rhodes
May 1, 1988·The Journal of Clinical Investigation·J E BirdR C Blantz
Jan 1, 1989·Circulation·J NejimaS F Vatner
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Sep 1, 1986·Clinical Science·R HanssonJ Waldenström
Sep 1, 1988·Acta Physiologica Scandinavica·S BratellT Scherstén
Nov 1, 1988·Circulation Research·Y TamuraB R Lucchesi
Jun 1, 1988·Journal of the American College of Cardiology·J L MehtaP Mehta
Jan 1, 1988·Nephron·C CanaveseA Vercellone
Feb 1, 1988·American Heart Journal·R FerreiraA Boveris
Apr 1, 1988·Kidney International·M S Paller
Dec 1, 1986·Circulation·G AmbrosioM L Weisfeldt
Nov 1, 1985·Annals of Surgery·G L BakerA P Autor
Dec 1, 1985·Transplantation·I KoyamaM J Im
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Feb 1, 1984·The Journal of Clinical Investigation·B D MyersS Friedman
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Jan 1, 1983·Nephron·C C Gornick, C M Kjellstrand
Feb 1, 1983·The American Journal of Medicine·S H HouJ T Harrington
May 1, 1983·Circulation·J L RomsonB R Lucchesi
Mar 1, 1980·Transplantation·D BrophyC M Kjellstrand
Citations
Jan 1, 1995·Pharmacology & Therapeutics·C Fleck, H Bräunlich
Feb 23, 1995·Biochimica Et Biophysica Acta·M KadkhodaeeM Cross
Jan 1, 1994·Journal of Drug Targeting·K MiharaM Hashida