PMID: 6405876May 14, 1983Paper

Lack of effect of beta-blocker on flat dose response to thiazide in hypertension: efficacy of low dose thiazide combined with beta-blocker

British Medical Journal
G A MacGregorJ Roulston


Increasing the dose of a thiazide diuretic used alone in patients with essential hypertension has little further effect on blood pressure but increases the deleterious metabolic consequences of the diuretic. The effect of a beta-blocker on this flat dose response is not known. In two randomised crossover studies the effect of 12.5 mg, 25 mg, and 50 mg hydrochlorothiazide combined with 400 mg acebutolol was assessed. The mean fall in supine blood pressure was about 15% and was the same whatever dose of thiazide was used with the beta-blocker. As the dose of hydrochlorothiazide was increased, however, there was evidence of increasing metabolic consequences of the diuretic. The study did not define the minimum dose of diuretic, and doses of hydrochlorothiazide lower than 12.5 mg might be as effective. These results suggest that many patients who are being treated with a combination of a beta-blocker and a diuretic are receiving unnecessarily large amounts of the diuretic without benefit to their blood pressure and with adverse metabolic consequences.


Aug 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Roulston, G A MacGregor
Aug 1, 1975·British Heart Journal·C F GeorgeA Petrie
Nov 9, 1963·Lancet·W I CRANSTONL M MUTCH


Jan 1, 1987·European Journal of Clinical Pharmacology·A SalvettiL Papi
Sep 12, 2006·European Journal of Clinical Pharmacology·H KnaufE Mutschler
Oct 1, 1987·American Heart Journal·B N Prichard, B Tomlinson
Jun 1, 1991·British Journal of Clinical Pharmacology·R DonnellyH L Elliott
Jan 1, 1986·Current Medical Research and Opinion·H R Lubis Yushar
Sep 18, 1987·The American Journal of Cardiology·G A MacGregor
Nov 1, 1992·International Journal of Cardiology·C M SteinT Kusemamuriwo
Feb 22, 1996·The American Journal of Cardiology·N M Kaplan
Mar 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·J S CorcoranJ S Yudkin
Jun 1, 1986·Hypertension·P F Magee, E D Freis
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M G ZieglerV Solt-Buzsaki
Jan 1, 1986·British Journal of Clinical Pharmacology·B N Prichard, C W Owens

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