PMID: 1149779Apr 11, 1975

Lack of effect of cholestyramine on the pharmacokinetics of clofibrate in man

European Journal of Clinical Investigation
A Sedaghat, E H Ahrens

Abstract

The study was undertaken to determine whether cholestyramine (16 g daily) interfered with clofibrate absorption when the two drugs were given together. Fifteen patients taking 1 g of clofibrate twice daily (for 2 to 416 weeks) participated in the study. Clofibrate (as the acid, p-chlorophenoxyisobutyric acid, CPIB) was quantified by thin-layer and gas-liquid chromatography. In patients taking clofibrate only, mean plasma CPIB concentration before the morning dose of clofibrate was 123 mug/ml. Peak levels were reached 3.5 hours after drug intake, the mean peak plasma CPIB concentration being 193 mug/ml. Absorption of CPIB exceeded 99%. Ninety-eight percent of the daily CPIB-intake was excreted in the urine, 61% being conjugated. In vivo degradation of CPIB did not occur. Free and conjugated CPIB was present in bile (mean fasting level being 55 mug/ml. The decay of radioactive CPIB in plasma was not log-linear: the mean t 1/2 of the first exponential was 0.45 hours, and of the second 15.1 hours. The pool size in 3 patients 3 hours after the morning dose of clofibrate was 1054 mg. CPIB was not detectable in adipose tissue, and kinetic data gave no hint of drug accumulation in patients on long-term therapy. In 6 patients given chol...Continue Reading

References

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Citations

Jun 12, 1979·European Journal of Clinical Pharmacology·R GuglerJ Hartlapp
Jun 1, 1980·European Journal of Clinical Pharmacology·C Harvengt, J P Desager
Apr 1, 1980·European Journal of Clinical Pharmacology·U AbshagenJ Marinow
Apr 1, 1977·Atherosclerosis·R PichardoJ Davignon
Jan 1, 1987·Pharmacology & Therapeutics·F M Williams
Jan 1, 1988·Pharmacology & Therapeutics·C R Sirtori, G Franceschini
May 1, 1979·Clinical and Experimental Pharmacology & Physiology·E M Faed, E G McQueen
Mar 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M N CayenD Dvornik
Dec 1, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M YamazakiJ H Lin
Mar 1, 1978·Clinical and Experimental Pharmacology & Physiology·E M Faed, E G McQueen

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